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TranscriptomicsTranscription profiling by array of whole blood from sickle-cell disease patients using globin mRNA reduction
Room temperature whole blood mRNA stabilization procedures, such as the PAX gene system, are critical for the application of transcriptional analysis to population-based clinical studies. Global transcriptome analysis of whole blood RNA using microarrays has proven to be challenging due to the high ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16728 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling and Sequencing of differentiated Human Hematopoietic Stem cells Reveal Lineage Specific Expression and Alternative Splicing of Genes
Hematopoietic differentiation is strictly regulated by complex network of transcription factors that are controlled by ligands binding to cell surface receptors. Disruptions of the intricate sequences of transcriptional activation and suppression of multiple genes cause hematological diseases, such...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-29989 | biostudies-arrayexpress
TranscriptomicsHeme-Bound Iron Activates Placenta Growth Factor via Erythroid KrM-CM-
We have tested the effect of iron on the gene expression profile in human leukemia cells with properties of erythroid differentiation. 12 Total samples were analyzed. We compared the gene expression profiles of cells treated with iron mesoporphyrin to mesoporphyrin alone. DMSO vehicle was also teste...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-52087 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells treated with rabbit anti-thymocyte globulin (rATG) or horse ATG (hATG)
We performed microarray to compare gene expression patterns of PBMC treated with rATG or hATG. Fold changes were compared using 2-way ANOVA tests for untreated, rATG- and hATG-treated PBMC. In PBMC treated with 10 ug/mL rATG, compared with untreated PBMC, 478 genes showed up-regulation, and 341 gene...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-10040 | biostudies-arrayexpress
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