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TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia [mRNA]
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47533 | biostudies-arrayexpress
UnknownChromosome-level assembly reveals a putative Y-autosomal fusion in the sex determination system of the Greenland Halibut (Reinhardtius hippoglossoides).
Not available
S-EPMC8727965 | biostudies-literature
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia [miRNA]
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47532 | biostudies-arrayexpress
TranscriptomicsJMJD2B knockdown treatment in normoxia and hypoxia
Estrogen receptor alpha plays a critical role in breast cancer and is a major target in endocrine therapy. HIF-1 alpha have been associated with ER alpha and predict a worse outcome. Recent studies indicate that histone demethylase JMJD2B is a HIF-1 alpha target. However, little is known about the b...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-18384 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia (miRNA-Seq)
Purpose: We aimed to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. Methods: microRNA sequencing...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47602 | biostudies-arrayexpress
TranscriptomicsA statistical method for detecting genomic aberrations in heterogeneous tumour samples from single nucleotide polymorphism genotyping data
SNP array analysis of microdissected tumor vs stroma vs surgically obtained tumor DNA was extracted from total tumor material, from microdissected stroma and microdissected, pure tumor tissue
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23785 | biostudies-arrayexpress
TranscriptomicsIdentification of microRNAs association with Rheumatoid Arthritis Synovial Fibroblasts using the Human TNF Transgenic Mouse Model
OBJECTIVE: MicroRNAs (miRNAs, miRs), a class of small non-coding RNA molecules, are posttranscriptional regulators involved in a plethora of cellular functions and have been proposed as potential therapeutic targets in various diseases, including rheumatoid arthritis (RA). In this study, we sought t...
ORGANISM(S): Mus musculus 
2012-05-13 | E-GEOD-31667 | biostudies-arrayexpress
GenomicsA large fraction of extragenic RNA Pol II transcription sites overlap enhancers (2)
Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are product...
ORGANISM(S): Mus musculus 
2010-05-21 | E-GEOD-19991 | biostudies-arrayexpress
TranscriptomicsA large fraction of extragenic RNA Pol II transcription sites overlap enhancers
Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are product...
ORGANISM(S): Mus musculus 
2010-05-21 | E-GEOD-20370 | biostudies-arrayexpress
GenomicsHigh resolution genome-wide mapping of HIF binding sites by ChIP-seq
We report ChIP-Seq analysis of HIF-1 alpha, HIF-2 alpha, and HIF-1 beta binding in MCF-7 breast cancer cells Sample analysis compared to pre-immune serum chromatin immunoprecipitation
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28352 | biostudies-arrayexpress
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