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TranscriptomicsTranscriptome analysis of normal erythroid progenitors and erythroleukemia cells
We compared the transcriptomes of ES cell derived erythroid progentor cells (ES-EP) and murine erythroleukemia (MEL) cells stably transfected with Gata-1 fused to ER. RNA was isolated from duplicate proliferating cultures of MEL and ES-EP using Affymetrix GeneChip Mouse Gene 1.0 ST.
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21949 | biostudies-arrayexpress
GenomicsGenome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with ge...
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21950 | biostudies-arrayexpress
TranscriptomicsExercise-induced mitochondrial translocation of p53 repairs mitochondrial DNA mutations
Exercise is a fundamental component of human health that is associated with greater life expectancy and reduced risk of chronic diseases. While the beneficial effects of endurance exercise on human health are well established, the molecular mechanisms responsible for these observations remain unclea...
ORGANISM(S): Mus musculus 
2015-12-11 | E-GEOD-75869 | biostudies-arrayexpress
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