Genome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells

ABSTRACT: We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with gene expression analysis, we show PU.1 directly regulates several critical signaling pathways in erythroid cells. Assaying PU.1 occupancy in normal and leukemic erythroid cells

ORGANISM(S): Mus musculus

SUBMITTER: Sandeep Wontakal 

PROVIDER: E-GEOD-21950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress