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GenomicsComparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates
Here, we demonstrate that Nematostella vectensis, Ciona intestinalis, Apis mellifera, and B. mori, show two distinct populations of genes differentiated by gene-body CpG density. Genome-scale DNA methylation profiles for A. mellifera spermatozoa reveal CpG-poor genes are methylated in the germ line,...
ORGANISM(S): Apis mellifera 
2011-06-16 | E-GEOD-29982 | biostudies-arrayexpress
TranscriptomicsIdentification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ~50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-56606 | biostudies-arrayexpress
GenomicsComparative methylome analysis of benign and malignant peripheral nerve sheath tumors
Aberrant DNA methylation (DNAm) was first linked to cancer over 25 years ago. Since then, many studies have associated hypermethylation of tumour suppressor genes and hypomethylation of oncogenes to the tumourigenic process. However, most of these studies have been limited to the analysis of promote...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21714 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human first and thrid trimester placenta and whole blood
Fifteen DNA methylation array experiments were performed on five human chromosome specific array platforms (NimbleGen: HG18_CHR13_FT, HG18_CHR18_FT, HG18_CHR21_FT, HG18_CHRX_FT, HG18_CHRY_FT), comparing: (1) one female whole blood immunoprecipitated DNA fragments to their input DNA, (2) one 1st tri...
ORGANISM(S): Homo sapiens 
2009-05-01 | E-TABM-507 | biostudies-arrayexpress
TranscriptomicsTiling path analysis to map chromatin anchors within the human Major Histocompatability Complex region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts
Mapping of chromatin anchors within the human Major Histocompatability Complex (MHC) region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts.
ORGANISM(S): Homo sapiens 
2008-10-01 | E-MEXP-1793 | biostudies-arrayexpress
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