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TranscriptomicsTranscription profiling of human MCF-7 breast cancer cells treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT)
MCF-7 breast cancer cells were treated with E2, ICI 182,789 (ICI), Raloxifene (Ral), and/or trans-hydroxytamoxifen (TOT) for 8 or 48 h. Duplicate samples are labeled set A or set B.
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-848 | biostudies-arrayexpress
TranscriptomicsSpecific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland
The efficacy and exceptionally good tolerance of estrogen blockade in the treatment of breast cancer is well recognized but novel agents are required, especially to take advantage of the multiple consecutive responses obtained in breast cancer progressing following previous hormone therapy, thus del...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-35206 | biostudies-arrayexpress
UnknownCo-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants.
Not available
S-EPMC10582660 | biostudies-literature
TranscriptomicsRaloxifene Attenuates Gas6 and Apoptosis in Experimental Aortic Valve Disease in Renal Failure
Introduction: Renal failure is associated with aortic valve calcification. Using our rat model of uraemia-induced reversible aortic valve calcification, we assessed the role of apoptosis and survival pathways in aortic valve calcification. We also explored the effects of raloxifene - an estrogen rec...
ORGANISM(S): Rattus norvegicus 
2010-05-11 | GSE21771 | GEO
UnknownA phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19.
Not available
S-EPMC9098200 | biostudies-literature
TranscriptomicsTranscription profiling of human MCF-7 breast cancer cell line transfected with adenovirus expressing Erbeta treated with estrogen or tamoxifen reveals tamoxifen can selectively regulate a unique set of >60 genes, which are minimally regulated by estradiol (E2) or raloxifene.
The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen can also have some estrogen-like agonist effects. Here, we rep...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4025 | biostudies-arrayexpress
GenomicsESR1 mutations maintain higher ER pathway activity relative to vehicle and ERa-WT controls following treatment with Raloxifene or fulvestrant.
ESR1 mutations maintain higher ER pathway activity relative to vehicle and ERa-WT controls following treatment with Raloxifene or fulvestrant.
PRJNA475477 | ENA
UnknownPharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis.
Not available
S-EPMC7479487 | biostudies-literature
UnknownEfflux and uptake transport and gut microbial reactivation of raloxifene glucuronides.
Not available
S-EPMC11659111 | biostudies-literature
UnknownRaloxifene/Vitamin D Combination Therapy vs. Raloxifene Monotherapy on Serum 25-Hydroxy-Vitamin D Level among Postmenopausal Women with Osteoporosis or Osteopenia: A Randomized Controlled Trial.
Not available
S-EPMC9511125 | biostudies-literature
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