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ProteomicsIn silico approach and mass spectrometry-based proteome profiling unravel IGF-1R inhibition potential of 3-(2-furoyl)-indole scaffolds in hepatocellular carcinoma
Considering the multi-targeting potential of furan-indole hybrids as anticancer agents, this study aimed to unveil the mechanism of new 3-(2-furoyl)-indole derivatives for their cytotoxicy on hepatocellular carcinoma cells. Initially, we conducted an in vitro cytotoxicity assay for thirteen 3-(2-f...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD054680 | Pride
Igf-1r Hepatocellular carcinoma Label-free proteomics 3-(2-furoyl)-indole Egfr 
ProteomicsTemperature and Time-Dependent Stability Assessment of Mice Tissue Proteins Using Label-Free Quantitative Proteomics by Mass Spectrometry
Protein biomarkers in disease conditions offer crucial insights into prognosis and treatment options. In research, where protein samples are frequently stored at -20°C and -80°C for extended periods, assessing protein stability under these conditions is essential. We assessed the stability of protei...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-02 | PXD057951 | Pride
Tissue proteins  protein stability  disease biomarkers  mass spectrometry  proteomic analysis 
GenomicsWhole exome sequencing of small cell neuroendocrine cancer of the cervix
In order to improve treatment selection for high grade neuroendocrine carcinomas of the cervix (NECC), we performed a comparative genomic analysis between this rare tumor type and other cervical cancer types, as well as extra-cervical neuroendocrine small cell carcinomas of the lung and bladder. We ...
EGAS00001003142 | EGA
UnknownRandomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
Not available
S-EPMC5478045 | biostudies-literature
UnknownRandomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC5321098 | biostudies-literature
UnknownDirected Structural Evolution of Nickel Nanoparticles into Atomically Dispersed Sites for Efficient CO<sub>2</sub> Electroreduction.
Not available
S-EPMC12508711 | biostudies-literature
UnknownThe combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo.
Not available
S-EPMC3433638 | biostudies-literature
UnknownPotential of Finger Millet Indigenous Rhizobacterium Pseudomonas sp. MSSRFD41 in Blast Disease Management-Growth Promotion and Compatibility With the Resident Rhizomicrobiome.
Not available
S-EPMC5974220 | biostudies-literature
UnknownPotential Pitfalls in Wastewater Phosphorus Analysis and How to Avoid Them.
Not available
S-EPMC8168049 | biostudies-literature
UnknownTargeting Transient Receptor Potential Melastatin-2 (TRPM2) Enhances Therapeutic Efficacy of Third Generation EGFR Inhibitors against EGFR Mutant Lung Cancer.
Not available
S-EPMC11425210 | biostudies-literature
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