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TranscriptomicsEWS TC-71 cell lines: IGF-1R resistant
Ewing's Sarcoma cell lines were made resistant to different IGF-1R drugs to investigate mechanisms and pathways modulated by the resistance. EWS TC-71 cell line was exposed to increasing concentration to three different anti-IGF-1R drugs (HAb AVE1642, TKI NVP-AEW541, HAb CP-751,871, cell lines name...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-34027 | biostudies-arrayexpress
ProteomicsIn vitro proteomic expression changes in Ewing sarcoma cell lines after IGF-1R or IGF-1R/IR blockade
Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pat...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-78121 | biostudies-arrayexpress
TranscriptomicsRNA-seq of IGF-1R in atherosclerosis
The aim of the project is to investigate whether endothelial-restricted augmentation of IGF-1 signaling is sufficient to suppress atherogenesis. We generated RNA-seq data from mice with endothelial-restricted over-expression of human wildtype IGF-1R (hIGFREO/ApoE-/-) or a signaling defective K1003R ...
ORGANISM(S): Mus musculus 
2025-07-31 | E-MTAB-14458 | biostudies-arrayexpress
ProteomicsReduced IGF-1 signaling fails to limit Alzheimer’s disease progression in a novel rat model of IGF-1R haploinsufficiency
The growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling pathway has been strongly implicated in the aging process. Lifespan is profoundly increased in both male and female dwarf mice, while low IGF-1 signaling per se leads to more modest improvements in female lifespan. However, as oppo...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-27 | PXD068498 | Pride
Insulin resistance Alzheimer’s disease Igf-1r Rat Igf-1 
GenomicsRNA-seq of IGF-1R in atherosclerosis
RNA-seq of IGF-1R in atherosclerosis
PRJEB80308 | ENA
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
TranscriptomicsIn vivo gene expression changes in EW5 Ewing sarcoma xenografts after IGF-1R or mTOR blockade
Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pat...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-67529 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of IR-/-, IGF-1R-/- (dKO) newborn epidermis.
Analysis of newborn mouse epidermis lacking the expression of Insulin receptor (IR) and Insulin like growth factor 1 receptor (IGF-1R). Results show that IR/IGF-1R signalling control epidermal morphogenesis. RNA was isolated from newborn mouse epidermis.Gene expression profiling was on on Affymetrix...
ORGANISM(S): Mus musculus 
2013-05-18 | E-GEOD-47065 | biostudies-arrayexpress
ProteomicsIn silico approach and mass spectrometry-based proteome profiling unravel IGF-1R inhibition potential of 3-(2-furoyl)-indole scaffolds in hepatocellular carcinoma
Considering the multi-targeting potential of furan-indole hybrids as anticancer agents, this study aimed to unveil the mechanism of new 3-(2-furoyl)-indole derivatives for their cytotoxicy on hepatocellular carcinoma cells. Initially, we conducted an in vitro cytotoxicity assay for thirteen 3-(2-f...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD054680 | Pride
Igf-1r Hepatocellular carcinoma Label-free proteomics 3-(2-furoyl)-indole Egfr 
ProteomicsIn vivo proteomic expression changes in EW5 Ewing sarcoma xenografts after IGF-1R and/or mTOR blockade
Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pat...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-78123 | biostudies-arrayexpress
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