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ProteomicsCortical region confers neuron-type-specific vulnerability to human APP expression
Alzheimer’s Disease is a devastating and an irreversible neurodegenerative disease currently afflicting 50 million individuals worldwide, a number expected to escalate three-fold over the next 25 years. Preventative treatment is of dire importance, and yet, cellular mechanisms underlying early regio...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-28 | PXD053491 | Pride
App  inhibition  pv interneuron  hyperexcitability  lateral entorhinal cortex  alzheimer’s disease 
ProteomicsSimultaneous profiling of native-state proteomes and transcriptomes of brain cell types using proximity labeling
Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances only modestly correlate with each other, complementary profiling...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-02-16 | PXD073954 | Pride
Proximity labeling  transcriptomics  proteomics  microglia  astrocytes  neurons  mrna-protein concordance 
ProteomicsSimultaneous profiling of native-state proteomes and transcriptomes of brain cell types using proximity labeling
Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances only modestly correlate with each other, complementary profiling...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-16 | PXD059818 | Pride
Proximity labeling  transcriptomics  proteomics  microglia  astrocytes  neurons  mrna-protein concordance 
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