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TranscriptomicsRNA-seq of human skin fibroblasts from healthy and systemic sclerosis patients with varying matrix stiffness
This study explores how increased matrix stiffness alters fibroblast transcription and its impact on the lineage specification of fibroblast subpopulations in fibrotic skin. Fibroblasts from healthy and systemic sclerosis patients were cultured in a collagen I-based 3D system with varying matrix sti...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14804 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of murine G-MDSCs after co-culture with ILC2s and control G-MDSCs
This experiment aimed to characterize the transcriptional response of murine granulocytic myeloid-derived suppressor cells (G-MDSCs) upon interaction with group 2 innate lymphoid cells (ILC2s). G-MDSCs were isolated from the bone marrow of C57BL/6 mice, while ILC2s were induced in vivo by hydrodynam...
ORGANISM(S): Mus musculus 
2026-10-01 | E-MTAB-16286 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human synovial joints from healthy donors
Human synovial Single cell RNA-seq was performed on three tissue samples from healthy donors. This experiment was done to explore the heterogeneity of cells in healthy human synovial joint and enabled the comparison of cellular states and composition to those of publicly available single cell RNA-se...
ORGANISM(S): Homo sapiens 
2024-08-06 | E-MTAB-14339 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human enthesis from healthy and inflamed tissues
Enthesitis is a characteristic feature of the course of psoriatic arthritis (PsA). To date, most data on enthesitis in PsA have been based on clinical assessment as well as MRI or ultrasound, due to the challenge of obtaining good quality enthesal tissue for molecular analysis. To date, there are no...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-15133 | biostudies-arrayexpress
TranscriptomicsGeoMx digital spatial profiling on enthesis biopsies from psoriatic arthritis patients before and after treatment with secukinumab
Enthesitis, a hallmark of psoriatic arthritis (PsA), reflects the interplay between mechanical stress and immune dysregulation at tendon-bone interfaces. We aimed to investigates the cellular and molecular responses in entheseal tissues following IL-17A inhibition in patients with active PsA. To ide...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-15134 | biostudies-arrayexpress
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