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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsRNA-Seq after knockdown of the endogeneous retrovirus HERVH in human embryonic stem cells
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements whose members are expressed preferentially in human pluripotent stem cells. Here, we report that the long-terminal repeat regions of HERVH function as enhancers which are regulated by OCT4. Strikingly, we found that ...
ORGANISM(S): Homo sapiens 
2014-03-30 | E-MTAB-2072 | biostudies-arrayexpress
TranscriptomicsDetermination of genes affected by HERVH depletion
The unique cellular state of embryonic stem cells is maintained by pluripotency-associated transcription factors such as OCT4. The transcriptional regulatory circuitries between human and mouse pluripotent stem cells exhibit notable differences. Transposable elements have altered the pluripotency ne...
ORGANISM(S): Homo sapiens 
2014-03-30 | E-GEOD-42430 | biostudies-arrayexpress
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