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TranscriptomicsFGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma
This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. ...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-45929 | biostudies-arrayexpress
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
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