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TranscriptomicsExpression in wild type and TgDREAM mouse B cells unstimulated or 2 days after LPS+IL4 stimulation
DREAM/KChIP-3 is a calcium-dependent transcriptional repressor highly expressed in immune cells. Transgenic mice expressing a dominant active DREAM mutant show reduced serum immunoglobulin levels. In vitro assays show that reduced immunoglobulin secretion is an intrinsic defect of transgenic B cells...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-16874 | biostudies-arrayexpress
GenomicsGenome wide localization of CTCF in activated mouse B cells
Identify CTCF binding sites in activated mouse B cells. Single ChIP experiment
ORGANISM(S): Mus musculus 
2011-11-19 | E-GEOD-33819 | biostudies-arrayexpress
TranscriptomicsGenome-wide survey of large rare copy number variations in Alzheimer’s disease among Caribbean Hispanics
Recently genome-wide association studies have identified significant association between Alzheimer’s disease and variations in CLU, PICALM, BIN1, CR1, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7. However, the pathogenic variants in these loci have not yet been found. We conducted a genome-wide scan f...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-33528 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ on resting (R) and stimulated (S) B cells from several IgH 3'RR mutant models
We evaluated by RNA-seq obveral transcripts in B cells (resting and activated for 2 days with LPS) sorted from several KO mice models devoid of portion or all the IgH 3' Regulatory Region One RNA-seq point was realized per condition (resting or stimulated) and per genotype. Each point corresponds to...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76217 | biostudies-arrayexpress
TranscriptomicsA mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Igh/Myc translocations underlie both sporadic Burkitt lymphoma (BL) and the endemic clinical form affecting African children infected with malaria. However, while sporadic translocations decapitate Myc from 5' proximal regulatory elements, most endemic events occur hundreds of kilobases away from My...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48514 | biostudies-arrayexpress
TranscriptomicsDigital gene expression analysis reveals genes associated with hexythiazox resistance in citrus red mite, Panonychus citri
We compared a miticides resistant strain and a susceptible strain's gene expression profile to reveal genes associated with miticide resistance in Panonychus citri.
ORGANISM(S): Panonychus citri 
2013-06-11 | E-MTAB-1193 | biostudies-arrayexpress
TranscriptomicsProfiling livers from LPS-treated rats
This program addresses the gene signature associated with LPS-treated liver in rat. Specifically, which genes are differentially expressed in livers of the Sprague Dawley rats treated with LPS? The LPS-treated liver profiling data was analyzed by identifying genes that were up- and down-regulated at...
ORGANISM(S): Rattus norvegicus 
2013-03-22 | E-GEOD-38078 | biostudies-arrayexpress
GenomicsDevelopmental Profile of DNA Methylation in the Developing Heart
Background: To better understand the role DNA methylation plays in regulating gene expression in the developng heart and furthermore the role it plays in heart development we performed genome wide DNA methylation profiling of embryonic hearts at embryonic day (E)11.5 and E14.5 using methyl sensitiv...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-55141 | biostudies-arrayexpress
GenomicsRPA accumulation during class switch recombination represents 5'-3' DNA end resection during the S-G2/M phase of the cell cycle
AID promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in G1. RPA is a ssDNA-binding protein that associates with resected DSBs in the S phase and facilitates the assembly of factors involved in homologous repair (HR) such as R...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-42451 | biostudies-arrayexpress
no omics definedChromatin immunoprecipitation of ATF3-/- mouse bone marrow macrophages with and without stimulation with lipopolysaccharide for 1 or 2 hours
DNA binding determination for ATF3 -/- macrophages without stimulation and with stimulation by LPS after 1 or 2 hours.
ORGANISM(S): Mus musculus 
2006-07-07 | E-MEXP-730 | biostudies-arrayexpress
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