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MetabolomicsPlatycodin D attenuates alcohol-associated fatty liver disease by suppressing TLR4–NF-κB and activating PPAR signaling

Alcohol-associated fatty liver disease (AFLD) is driven by ethanol-induced metabolic dysregulation and hepatic inflammation, with gut dysbiosis and endotoxin-triggered innate immune activation implicated in disease progression. Platycodin D (PD), a triterpenoid saponin from Platycodon grandifloru...

2026-01-12 | MTBLS13658 | MetaboLights
UnknownPrevalence, spectrum and aetiology of valvular heart disease based on community echocardiographic screening transition from different altitudes in Yunnan, China.
Not available
S-EPMC12573351 | biostudies-literature
GenomicsMapping of 5-hydroxymethylcytosine by selective chemical labeling (SCL-seq) in human naive B cells and in vitro differentiated plasmablasts (P1 cells) [HTS]
We report the genome-wide mapping of 5hmC in naive B cells and in vitro differentiated plasmablasts (P1 cells). In addition, H3K4me1 and H3K27ac histne marks were mapped in in vitro differentiated plasmablasts from two healthy donors (BN358 and BN369) by ChIP-seq. Genomic DNA from human primary cell...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-72360 | biostudies-arrayexpress
MetabolomicsFermented cotton stalks preserve colonic epithelial integrity in Hu sheep by modulating the microbiota–metabolite–NF-kB/MLCK axis

This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

2026-03-18 | MTBLS14078 | MetaboLights
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
ProteomicsCellular senescence escape and antiviral response discriminate glioblastoma from lower grade gliomas
Cellular senescence is a negative prognostic indicator in glioblastoma (GB). However, the specific cell types exhibiting senescence and the molecular mechanisms by which senescent cells (SCs) contribute to GB pathogenesis remain unknown. We performed multi-omics integration of publicly available GB ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071225 | Pride
MetabolomicsBioconversion properties and anti-hyperuricemic capacity of urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) beverage

Hyperuricemia (HUA) is a global metabolic disorder characterized by abnormally elevated serum uric acid (UA) (SUA) level, and this study aimed to design a functional fermented beverage based on the urate-lowering probiotic Lactobacillus paracasei N1115 (LP) and Aronia melanocarpa (black chokeberr...

2025-11-28 | MTBLS13414 | MetaboLights
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