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ProteomicsTMT-MS2_cellular adaptation to hypomorphic alleles of essential gene NUP58
Adaptive evolution in response to cellular stress is a critical process implicated in a wide range of core biological and clinical phenomena. Two major routes of adaptation have been identified: non-genetic cellular plasticity, which allows expression of different phenotypes in novel environments, a...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD022255 | Pride
Tmt-ms2 Crispr-cas9 Cellular adaptation Nup58 Essential gene 
ProteomicsThe Greatwall kinase safeguards the genome integrity by balancing the kinome activity in mitosis.
Mastl is commonly overexpressed in cancer, appearing as an alternative therapeutic anticancer target. Loss of Mastl induces multiple chromosomal mitotic errors that lead to the accumulation of micronuclei and multilobulated cells with polyploidy. Our detailed analyses display that loss of Mastl quic...
ORGANISM(S): Mus Musculus (mouse) 
2020-10-15 | PXD019297 | JPOST Repository
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