Sort   by:  
 Page size 
ProteomicsThe dopamine transporter antiports potassium to increase the uptake of dopamine
The dopamine transporter facilitates dopamine reuptake from the extracellular space to terminate neurotransmission. The transporter belongs to the neurotransmitter:sodium symporter family, which includes transporters for serotonin, norepinephrine, and GABA that utilize the Na+ gradient to drive the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-20 | PXD032663 | Pride
Ms  membrane proteins  mass spectroemetry  hydrogen-deuterium exchange  transporter 
ProteomicsConformational dynamics of the human serotonin transporter during substrate and drug binding
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...
ORGANISM(S): Homo sapiens (Human) 
2019-05-15 | PXD013750 | Pride
Hdx-ms  protein-ligand interactions  membrane proteins  mass spectrometry 
ProteomicsSubstrate-induced conformational dynamics of the dopamine transporter
The dopamine transporter is a member of the neurotransmitter:sodium symporters (NSSs), which are responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Experimental evidence elucidating the coordinated conformational rearrangeme...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-11-12 | PXD013841 | Pride
Ms  protein-ligand interactions  membrane proteins  mass spectrometry 
Sort   by:  
 Page size