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UnknownGata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development.
Not available
S-EPMC8864660 | biostudies-literature
TranscriptomicsGlobal Gene Expression of hematopoietic stem cells expressing endogenous NrasG12D/G12D, NrasG12D/+, Nras+/+
Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (NrasG12D/+) in hematopoietic cells leads to expansion of myeloid progenitors, increased long-term reconstitution of bone marrow cells, and a chronic myeloproliferative neo...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-46948 | biostudies-arrayexpress
UnknownAn EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.
Not available
S-EPMC6117096 | biostudies-literature
UnknownA gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
Not available
S-EPMC10721149 | biostudies-literature
ProteomicsRole of GATA-2 -77 enhancer in murine blood progenitor cells
We discovered enhancers that control GATA-2 expression during mouse development and in adult and generated mutant mouse strains that lack these enhancers, and these mice have very specific and important phenotypes that revealed GATA-2 mechanisms to control stem and progenitor cell transitions. In th...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-05 | PXD013855 | Pride
Deep analysis Primary tissue Targeted proteomics Label-free proteomics 
UnknownPhase I study to evaluate toxicity and feasibility of intratumoral injection of α-gal glycolipids in patients with advanced melanoma.
Not available
S-EPMC4958541 | biostudies-literature
UnknownFollicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab.
Not available
S-EPMC6419437 | biostudies-literature
UnknownConstructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories.
Not available
S-EPMC7596813 | biostudies-literature
UnknownDownregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm.
Not available
S-EPMC6405304 | biostudies-literature
UnknownMolecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
Not available
S-EPMC3079277 | biostudies-literature
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