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TranscriptomicsGene expression profiles of neonatal cardiomyocytes and immortalized heart muscle cells exposed to inflammatory stimuli
We used a transcriptomic approach to systematically compare the response to inflammatory stimuli for two murine cardiomyocyte models. Our results indicate that murine neonatal cardiomyocytes (NNC) are able to exhibit a pronounced response upon inflammatory stimuli, while HL-1 cells were predominantl...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-56584 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsOxygen-dependent osteocyte transcriptomic adaptations occur without modulation of endothelial gene expression via osteocyte paracrine signaling
Bone regeneration remains clinically challenging, partly due to limited knowledge of the cellular mechanisms governing bone repair. Osteocytes, which constitute the majority of bone cells, form an dendritic network and are central regulators of skeletal homeostasis. Residing in a mineralized and low...
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-16618 | biostudies-arrayexpress
TranscriptomicsRNAseq of Calu-3 epithelial cells treated with Cyclosporin A
Calu-3 cells are human lung cancer cells that serve as a model of respiratory epithelial cell model. Here, Calu-3 cells are used as a cell system for Middle East respiratory syndrome coronavirus and treated with Cyclosporin A To assess the effect of Cyclosporin A on the host cells, uninfected cells ...
ORGANISM(S): Homo sapiens 
2020-08-01 | E-MTAB-8222 | biostudies-arrayexpress
TranscriptomicsThe genome of the seagrass Zostera marina
This dataset contains the transcriptome sequence of Zostera marina as produced by Illumina sequencing. Four tissues were sequenced, female flower in late and early stages of development, the male flower, the root and leaf tissue. Full transcriptome sequencing of four tissues, including female flower...
ORGANISM(S): Zostera marina 
2016-01-16 | E-GEOD-67579 | biostudies-arrayexpress
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35703 | biostudies-arrayexpress
TranscriptomicsRNAseq of the protease transcriptome of primary murine alveolar epithelial cells type II (AECII) and the murine lung cells MLE-15
RNAseq of primary murine alveolar epithelial cells type II (AECII) and the murine lung cells MLE-15 in order to identify potential candidates of trypsin-like proteases capable to cleave the influenza surface glycoprotein hemaglutinine (HA). AECII cells do support the cleavage of HA while MLE-15 cell...
ORGANISM(S): Mus musculus 
2020-03-27 | E-MTAB-8571 | biostudies-arrayexpress
TranscriptomicsAlterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior studies have suggested that the characteristic behaviors associated with escalation of drug use are caused, at least in part, by ethanol-ev...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73018 | biostudies-arrayexpress
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