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TranscriptomicsChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...
ORGANISM(S): Homo sapiens 
2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
UnknownThe methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
Not available
S-EPMC1360559 | biostudies-literature
UnknownP38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.
Not available
S-EPMC1383562 | biostudies-literature
UnknownChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
Not available
S-EPMC2254548 | biostudies-literature
UnknownDerangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.
Not available
S-EPMC2627936 | biostudies-literature
UnknownRARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.
Not available
S-EPMC2141839 | biostudies-literature
UnknownComprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Not available
S-EPMC2798864 | biostudies-literature
UnknownMechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580.
Not available
S-EPMC2891995 | biostudies-literature
TranscriptomicsEffect of T0901317, AM580 or T0901317+AM580 on monocyte gene expression
The aim of this study was to investigate the effect of T0901317 LXR agonist on Retinoic Acid Receptor (RAR) family gene expression. T0901317 alone increase RARalpha gene expression in monocytes and the effects of the co treatment of the cells with T0901317 and a specific RARalpha agonist (AM580) wer...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-13407 | biostudies-arrayexpress
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