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ProteomicsBioID proximity biotinylation-MS analysis of human main RAS GTPases in K-562 CML cells
The human main RAS GTPases (KRAS4A, KRAS4B, NRAS and HRAS) represent major hubs of cellular signal transduction and are highly mutated in various different cancer entities. RAS GTPases are tightly controlled via different molecular mechanisms in order to coordinate their cellular signaling activity ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-03 | PXD011280 | Pride
Ras gtpases Cml Lc-ms Bioid 
ProteomicsNovel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids
The small GTPases H, K, and NRAS are molecular switches that are indispensable for proper regulation of cellular proliferation and growth. Mutations in this family of proteins are associated with cancer and result in aberrant activation of signaling processes caused by a deregulated recruitment of d...
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD016827 | Pride
Ip-ms Protein-engineering Ras-binding domain 
UnknownEvolution of the Ras-like small GTPases and their regulators.
Not available
S-EPMC3116619 | biostudies-literature
TranscriptomicsPRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [expression array]
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, sug- gesting that this complex plays a dichotomous and poorly understood role in cancer2,3. Here we provid...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-62500 | biostudies-arrayexpress
GenomicsPRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [ChIP-seq]
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, suggesting that this complex plays a dichotomous and poorly understood role in cancer2,3. Here we provide ...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-62499 | biostudies-arrayexpress
TranscriptomicsRERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG exp...
ORGANISM(S): Homo sapiens 
2005-07-23 | E-GEOD-2987 | biostudies-arrayexpress
ProteomicsTargeting Ras-, Rho-, and Rab-Family GTPases via a Conserved Cryptic Pocket
The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) which comprise cellular switch networks that govern cell motility, growth, polarity, protein trafficking, and gene expres...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054414 | Pride
Gtpase 
UnknownStructural basis for LZTR1 recognition of RAS GTPases for degradation.
Not available
S-EPMC12516822 | biostudies-literature
TranscriptomicsRas-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model [DGE-Seq]
Ras-related associated with diabetes (RRAD) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues. However, the role of the methylation-induced RRAD inactivation in tumorigenesis remains unclear. In this study, the ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-55567 | biostudies-arrayexpress
GenomicsRas-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model (RRBS-Seq]
Ras-related associated with diabetes (RRAD) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues. However, the role of the methylation-induced RRAD inactivation in tumorigenesis remains unclear. In this study, the ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-55566 | biostudies-arrayexpress
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