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ProteomicsRASA3 identified as a potential effector of the brain G protein G⍺o by mass spectrometry
G⍺o, the alpha subunit of the most abundant heterotrimeric G protein in the brain, mediates signaling by opioids and by many neuromodulators to inhibit neural function. An open question is whether activated G⍺o-GTP directly binds to and regulates effector molecules, like all other animal G⍺ protein...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-23 | PXD069453 | Pride
Gtpase activating protein (gap) Proteomics Neurotransmitter signaling Heterotrimeric g protein Protein-protein interaction Rasa3 G⍺o 
GenomicsRASA3 regulates the balance of pTh17-Th2 reciprocal programs.
RASA3 regulates the balance of pTh17-Th2 reciprocal programs.
PRJNA437147 | ENA
GenomicsRASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
RASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
PRJNA1380299 | ENA
GenomicsRASA3 inhibits Tc1 differentiation and attenuates anti-bacteria immunity by restricting the HCK kinase
RASA3 inhibits Tc1 differentiation and attenuates anti-bacteria immunity by restricting the HCK kinase
PRJNA1491702 | ENA
TranscriptomicsRASA3 inhibits Th1 differentiation and attenuates inflammatory immune response by restricting the HCK kinase
Type I immunity is marked by IFN-γ, with Th1 cells as a key subset; however, intrinsic negative regulators of Th1 remain poorly defined. We identified RASA3 as such a regulator, whose expression declines during Th1 differentiation. T cell-specific RASA3 knockout enhances Th1 differentiation and exac...
ORGANISM(S): Mus musculus 
2026-07-05 | GSE313543 | GEO
TranscriptomicsRASA3 inhibits Tc1 differentiation and attenuates anti-bacteria immunity by restricting the HCK kinase
Type I immunity is defined by IFN-γ secretion, with Tc1 cells as a key subset, yet their intrinsic negative regulators remain unclear. We identified RASA3 as a novel negative regulator of Tc1 cells. T cell-specific deletion of RASA3 enhanced Tc1 differentiation and antibacterial immunity. We further...
ORGANISM(S): Mus musculus 
2026-07-09 | GSE337937 | GEO
UnknownMethylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma.
Not available
S-EPMC6010675 | biostudies-literature
UnknownRasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet.
Not available
S-EPMC4072513 | biostudies-literature
UnknownRasa3 regulates stage-specific cell cycle progression in murine erythropoiesis.
Not available
S-EPMC7856249 | biostudies-literature
UnknownRasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism.
Not available
S-EPMC5806903 | biostudies-literature
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