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TranscriptomicsDual role of EZH2 on megakaryocyte differentiation, analysis at different stages of maturation at day 9 of culture
EZH2, the enzymatic component of PRC2, has been identified as a key factor in hematopoiesis. EZH2 loss of function mutations have been found in myeloproliferative neoplasms, more particularly in myelofibrosis, but the precise function of EZH2 in megakaryopoiesis is not fully delineated. Here, we sho...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-8610 | biostudies-arrayexpress
TranscriptomicsIGR_Raslova_IPS
FPD/AML is a constitutional disorder characterized by germline abnormalities in the hematopoietic transcription factor RUNX1, also called AML1. Mouse models have revealed the essential role of Runx1 during the first steps of hematopoiesis with an embryonic lethality and a complete absence of definit...
ORGANISM(S): Homo sapiens 
2014-01-19 | E-MTAB-1526 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
TranscriptomicsDual role of EZH2 on megakaryocyte differentiation, analysis on mature megakaryocytes at day 13 of culture
EZH2, the enzymatic component of PRC2, has been identified as a key factor in hematopoiesis. EZH2 loss of function mutations have been found in myeloproliferative neoplasms, more particularly in myelofibrosis, but the precise function of EZH2 in megakaryopoiesis is not fully delineated. Here, we sho...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-8609 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tetraploid and polyploid (8N and 16N) megakaryocytes to identify genes which are up and down regulated during megakaryocyte differentiation/polyploidization
The aim of the experiment was to characterize by a pan-genomic approach genes which are continuously up and down regulated during polyploidization during megakaryocyte differentiation.
ORGANISM(S): Homo sapiens 
2007-04-16 | E-TABM-133 | biostudies-arrayexpress
GenomicsRole of trisomy 21, GATAs mutation and associated mutations in the development of a DS-AMKL model from IPSC: Cut&Tag
Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. We modelled this leukemic evolution through ...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-11032 | biostudies-arrayexpress
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