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TranscriptomicsPleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis and ATM-Mediated DNA Damage Response
Gene expression data from VHL teratomas comparing genes differentially expressed based on apoptotic response to tumor microenvironment. Abstract BACKGROUND: The risk relevance of the P81S von Hippel-Lindau (VHL) gene hotspot mutation identified in clear cell renal cell carcinoma from individuals ex...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-37464 | biostudies-arrayexpress
TranscriptomicsMeta-analysis of Clear Cell Renal Cell Carcinoma Gene Expression Defines a Variant Subgroup and Identifies Gender Influences on Tumor Biology
Clear cell renal cell carcinoma comprises two dominant subtypes, ccA and ccB, with gender disparity providing additional disease information. A third minor subgroup has distinct expression profiles consistent with von Hippel-Lindau wild type status and displays variant histology features. 44 new tum...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-33093 | biostudies-arrayexpress
TranscriptomicsIdentifying mRNA targets of microRNA in clear cell renal cell carcinoma
A bioinformatic approach to identify targets of microRNA in cancer. Keywords: Patient sample study Samples GSM413237-GSM413270: Total RNA from 17 RCC tumors and 17 corresponding non-tumor samples was hybridized against a common reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-16441 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples for HIF-alpha expression and VHL genotype, in order to define differentially expressed genes Keywords: Patient Sampl...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-11904 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples based on HIF-alpha expression, in order to examine levels of genomic DNA aberration. Keywords: Patient Sample Study ...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-13282 | biostudies-arrayexpress
UnknownSubset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation.
Not available
S-EPMC11607909 | biostudies-literature
UnknownObesity induces PD-1 on macrophages to suppress anti-tumour immunity.
Not available
S-EPMC11456854 | biostudies-literature
UnknownLigand-independent integrin β1 signaling supports lung adenocarcinoma development.
Not available
S-EPMC9462485 | biostudies-literature
UnknownComprehensive molecular profiling of lung adenocarcinoma.
Not available
S-EPMC4231481 | biostudies-literature
UnknownBelzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
Not available
S-EPMC9275515 | biostudies-literature
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