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ProteomicsHuntingtin interactome in human striatal neurons derived from iPSCs upon the induction of double strand break (DSB) DNA damage response
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059660 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
ProteomicsAscorbate peroxidase (APEX2) -mediated proximity-based proteomics for HTT protein interactions
Huntington’s Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD cellular pathogenesis and cellular functions of the normal and mutan...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD059663 | Pride
Huntington’s disease Protein interactions Huntingtin Dna damage Neurodegeneration 
ProteomicsPTMs of HTT protein - Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats
Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, causative of Huntington’s disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-06-29 | PXD005753 | Pride
Huntingtin Hd Human and mouse brain 
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