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TranscriptomicsProliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein-coding genes, including many involved in basal cellular processes and organismal development. Although both increases and decreases in the levels of specific miRNAs have been shown to promote tumor d...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-34825 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [Exon array]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44161 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44163 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [small_RNA-Seq]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44156 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [CLIP-Seq]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45828 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [RNA-seq_siRNA_transfection]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44157 | biostudies-arrayexpress
GenomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [ChIP-seq_histone]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44159 | biostudies-arrayexpress
GenomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [ChIP-seq_nr6a1]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44160 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [3p arrays]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44162 | biostudies-arrayexpress
TranscriptomicsLet-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [mRNA-seq_Flag-HA-NR6A1_overexpr]
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with incr...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-44158 | biostudies-arrayexpress
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