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UnknownPhagocytosis in the retina promotes local insulin production in the eye.
The retina is highly metabolically active, relying on glucose uptake and aerobic glycolysis. Situated in close contact to photoreceptors, a key function of cells in the retinal pigment epithelium (RPE) is phagocytosis of damaged photoreceptor outer segments (POS). Here we identify RPE as a local sou...
S-EPMC10457724 | biostudies-literature
UnknownRapid unleashing of macrophage efferocytic capacity via transcriptional pause release.
During development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis1. How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely underst...
S-EPMC12573440 | biostudies-literature
UnknownChimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation.
Our bodies turn over billions of cells daily via apoptosis and are in turn cleared by phagocytes via the process of "efferocytosis." Defects in efferocytosis are now linked to various inflammatory diseases. Here, we designed a strategy to boost efferocytosis, denoted "chimeric receptor for efferocyt...
S-EPMC9930200 | biostudies-literature
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