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TranscriptomicsEffect of LPS and LPS-binding protein treatment on RAW 264.4 cells
All samples were gathered from mouse RAW 264.7 cells (macrophages). Control total RNA was extracted from untreated RAW 264.7 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. Test total RNA was extracted from lipopolysaccharide (100ng/ml) and lipopolysaccharide-binding protein (100pM) treated RA...
ORGANISM(S): Mus musculus 
2004-03-04 | E-GEOD-1098 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of RAW 264.7 cells stimulated with the AS03 adjuvant after 4 and 8 hours
The Adjuvant System 03 (AS03) containing is an oil-in-water emulsion containing -tocopherol and squalene that is used in several licensed vaccines. However, the molecular mechanisms involved in its immunostimulatory properties are ill-defined. Here, we have investigated the response of myeloid RAW...
ORGANISM(S): Mus musculus 
2018-06-26 | E-MTAB-5962 | biostudies-arrayexpress
TranscriptomicsExpression data from RAW 264.7 macrophage
IFNg is a pro-inflammatory and pro-atherogenic cytokine that leads to macrophage activation. Adenosine has well-documented anti-inflammatory properties. We used microarrays to compare the global gene expression profile in mouse macrophages stimulated with IFNg alone and those cells treated with IFNg...
ORGANISM(S): Mus musculus 
2009-12-30 | E-GEOD-14612 | biostudies-arrayexpress
TranscriptomicsExpression data from BNL CL.2 liver cells when cultured with iron, RAW 264.7 macrophages or both
We found that co-culturing BNL CL.2 liver cells with RAW 264.7 macrophages increased IRP binding in the first. To further investigate this modulation we investigated the gene expression profile in BNL CL.2 cells cultured alone, with iron, with RAW 264.7 macrophages or in the presence of both iron an...
ORGANISM(S): Mus musculus 
2016-10-22 | E-GEOD-32090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse triplicate samples of RAW 264.7 murine macrophages either untreated, stimulated with 100 ng/ml LPS for 18 hours, or constituitively over-expressing CstF-64
Triplicate samples of RAW 264.7 murine macrophages either untreated, stimulated with 100 ng/ml LPS for 18 hours, or constituitively over-expressing CstF-64 were analyzed by microarray using Affymetrix murine gene chip 430A.
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-2002 | biostudies-arrayexpress
ProteomicsComaprison of the phagosome proteome of bone marrow-derived macrophages and RAW264.7
Macrophages are important immune cells operating at the forefront of innate immunity by taking up foreign particles and microbes through phagocytosis. The RAW 264.7 cell line is commonly used for experiments in the macrophage and phagocytosis field. However, little is known how its functions compare...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084938 | MassIVE
TranscriptomicsGene expression and synergistic interactions induced by CpG ODN and/or poly(I:C)
Bioinformatic analysis of microarray data was used to identify the regulatory patterns underlying changes in gene expression induced when RAW 264.7 macrophages were stimulated via TLR9 by CpG oligonucleotides (ODN) and/or via TLR3 by poly (I:C). While the genes activated by each ligand mediated simi...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-15416 | biostudies-arrayexpress
TranscriptomicsExpression data from LPS-stimulated RAW 264.7 mouse macrophages treated with Hypericum perforatum fraction and bioactive constituents
Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflam...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21841 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse RAW 264.7 cells treated with the oxidant hypochlorous acid (HOCl) - dose response
Hypochlorous acid (HOCl) is a potent oxidant that is produced endogenously in mammalian tissue by phagocytes. Exogenous exposure to HOCl also can occur following inhalation of chlorine gas. HOCl has been implicated as a source of oxidative stress associated atherosclerosis and other diseases. The...
ORGANISM(S): Mus musculus 
2009-04-12 | E-GEOD-15457 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine macrophage-like RAW 264.7 cells treated with EdTx, protective antigen, or LPS for different length of time to examine the effect of EdTx on global transcriptional profiles.
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstiti...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4712 | biostudies-arrayexpress
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