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ProteomicsSplenectomy of patients with hereditary spherocytosis improves erythrocyte functionality in a septin-dependent manner
Splenectomy improves clinical parameters of patients with hereditary spherocytosis but its potential benefit to red blood cell (RBC) morphology and deformability and the mechanism behind remain unknown. We here compared 7 non-splenectomized and 12 splenectomized patients with mutations in the β-spec...
ORGANISM(S): Homo sapiens (Human) 
2023-02-13 | PXD034588 | Pride
Calcium Red blood cell fragility Oxidative stress Extracellular vesicle release Rbc maturation Spectrin network Ankyrin 
ProteomicsComparison of the proteome of human adult and cord erythroid cells and changes in the proteome following reticulocyte maturation.
Cord blood stem cells are an attractive starting source for the production of red blood cells in vitro for therapy because of additional expansion potential compared to adult peripheral blood progenitors, and cord blood banks usually being more representative of national populations than blood donor...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD003276 | Pride
Human Reticulocytes Tmt labelling Erythroid cells Cord blood Nanolc-ms/ms 
TranscriptomicsGlobal discovery of erythroid long non-coding RNAs reveals novel regulators of red cell maturation
Erythropoiesis is regulated at multiple levels to ensure the proper generation of mature red cells under multiple physiological conditions. To probe the contribution of long non-coding RNAs (lncRNAs) to this process, we examined >1 billion RNA-Seq reads of polyadenylated and nonpolyadenylated RNA fr...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-52126 | biostudies-arrayexpress
UnknownIn-depth phenotypic characterization of reticulocyte maturation using mass cytometry.
Not available
S-EPMC6097872 | biostudies-literature
UnknownComparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation.
Not available
S-EPMC5083095 | biostudies-literature
TranscriptomicsStudies of Human Erythropoiesis Using classic 2D liquid culture and 3D scaffolds
Different bioengineering techniques have been developed to enable the production of erythrocytes in vitro. However, extrapolating the 3D structure and function of erythroblastic islands remains challenging. In our research, we employ a comprehensive strategy emphasizing physiological red blood cell ...
ORGANISM(S): Homo sapiens 
2025-02-17 | GSE289025 | GEO
UnknownSplenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects.
Not available
S-EPMC10468371 | biostudies-literature
TranscriptomicsInduced erythropoiesis during acute anemia in Atlantic salmon
Study was performed to improve understanding of erythropoiesis (EP) induced by acute anemia in Atlantic salmon. Fish was injected with a low dose of hemolytic compound phenylhydrazine (PHZ). Treatment resulted in moderate but significant reduction of hematocrit (Hct) and increased transcription of c...
ORGANISM(S): Salmo salar 
2013-03-26 | E-GEOD-45479 | biostudies-arrayexpress
UnknownSystemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.
Not available
S-EPMC10470790 | biostudies-literature
UnknownFerric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium.
Not available
S-EPMC10457393 | biostudies-literature
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