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TranscriptomicsRBFox2 regulates a broad RNA program and is required for genome-wide targeting of polycomb complex
Increasing evidence suggests that diverse RNA binding proteins interact with regulatory RNAs to regulate transcription. RBFox2 is a ubiquitous RNA binding protein with prevalent expression in stem cells, heart, and brain. Here, we report a systematic dissection of the RBFox2-regulated RNA program in...
ORGANISM(S): Mus musculus 
2015-10-22 | E-GEOD-57926 | biostudies-arrayexpress
TranscriptomicsRbfox2 controls autoregulation in RNA binding protein networks
We generated a global analysis of Rbfox2 splicing regulation combined with a highly specific, single nucleotide-resolution Rbfox2 RNA binding map. We found that Rbfox2 regulates the splicing and expression of many previously unknown targets, and particularly a number of RNA binding proteins (RBPs),...
ORGANISM(S): Mus musculus 
2014-03-17 | E-GEOD-54794 | biostudies-arrayexpress
TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [RNA-Seq]
RNA-seq analysis of samples from Non-silencing, RBFOX2 and CPSF2 knockdown cells We analyzed 6 samples using the Illumina HiSeq 2000. Sequence data was processed by DexSeq. Two biological replicates were performed for Non-silencing, RBFOX2 and CPSF2 knockdown cells
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60391 | biostudies-arrayexpress
TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [iCLIP-Seq]
iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies. iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies.
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60385 | biostudies-arrayexpress
TranscriptomicsRbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis
Purpose: The goals of this study are to compare transcriptomes using RNA-seq of mouse myoblasts (C2C12 cell line) in undifferentiated and differentiated states and with siRNA-mediated knock down of the RNA binding proteins, Rbfox1 (only expressed in differentiated state) and Rbfox2 (expressed in bot...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-58928 | biostudies-arrayexpress
GenomicsRbfox2 is necessary for cardiovascular development
Rbfox2 is necessary for cardiovascular development
PRJNA557594 | ENA
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
GenomicsRetinal transcriptome analysis of Rbfox2 deficient animals
Retinal transcriptome analysis of Rbfox2 deficient animals
PRJNA649688 | ENA
ProteomicsLiver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein-2 (RBFOX2) in mainta...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-28 | PXD036976 | Pride
Mouse Cholesterol Liver Splicing 
GenomicseiCLIP analysis of RBFOX2 in primary mouse hepatocytes
eiCLIP analysis of RBFOX2 in primary mouse hepatocytes
PRJNA637084 | ENA
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