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TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation (CLIP-Seq)
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-48066 | biostudies-arrayexpress
ProteomicsCharacterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease
RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs and their RNA-binding regions in the mammalian brain identifying 526 RBPs i...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-22 | PXD029227 | Pride
Rbm5 Mass spectrometry Brain-pclap Rna-protein interactions Rna-binding proteins Huntington’s disease 
GenomicsIdentification of RBM5 and RBM10-dependent splicing events in 293Flp-In cells.
Identification of RBM5 and RBM10-dependent splicing events in 293Flp-In cells.
PRJNA1003056 | ENA
GenomicsEffect of RBM5 knockout or overexpression on transcription in MOLM13 AML cells
Effect of RBM5 knockout or overexpression on transcription in MOLM13 AML cells
PRJNA936855 | ENA
GenomicsRBM5 and RBM10
RBM5 and RBM10
PRJNA1004300 | ENA
GenomicsGene Expression Analysis of RBM5 KO in Brain
Gene Expression Analysis of RBM5 KO in Brain
PRJNA528036 | ENA
UnknownA bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.
Not available
S-EPMC9763339 | biostudies-literature
TranscriptomicsIdentification of RBM5 and RBM10-dependent splicing events in 293Flp-In cells.
RBM5 and RBM10 are RNA-binding proteins and splicing regulators. These two proteins are putative paralogs in mammalian cells, sharing common domain organization and extensive protein sequence similarity, but their RNA-binding preferences differ. We developed a sensitive system to identify splicing e...
ORGANISM(S): Homo sapiens 
2024-03-08 | GSE240259 | GEO
TranscriptomicsEffect of RBM5 knockout or overexpression on transcription in MOLM13 AML cells
Background: The oncogenic protein HOXA9 plays a critical role in leukemia transformation and maintenance, and its aberrant expression is a hallmark of most aggressive acute leukemia. Although inhibiting the upstream regulators of HOXA9 has been proven as a significant therapeutic intervention, the c...
ORGANISM(S): Homo sapiens 
2023-11-16 | GSE225633 | GEO
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