Sort   by:  
 Page size 
GenomicsDNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis.
The relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutation of the H3K27 methyltransferase genes, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, result in re-replication (repeated origin firing within the same cell cycle). He...
ORGANISM(S): Arabidopsis thaliana 
2012-08-07 | E-GEOD-38286 | biostudies-arrayexpress
TranscriptomicsSingle-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination.
Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying these copy number changes are still incompletely unde...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-04 | E-GEOD-41259 | biostudies-arrayexpress
GenomicsDNA re-replication is susceptible to nucleotide level mutagenesis
DNA re-replication is susceptible to nucleotide level mutagenesis
PRJNA511875 | ENA
GenomicsFANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication
PRJNA1201078 | ENA
GenomicsIdentification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation
PRJEB27808 | ENA
GenomicsDNA re-replication is susceptible to nucleotide level mutagenesis
The sources of genome instability, a hallmark of cancer, remain incompletely understood. One potential source is DNA re-replication, which arises when the mechanisms that prevent re-initiation of replication origins within a single cell cycle are compromised. Using the budding yeast Saccharomyces ce...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-27 | GSE124382 | GEO
GenomicsGenome-wide mapping of DNA re-replication in S. cerevisiae
To maintain genomic stability, re-initiation of eukaryotic DNA replication within a single cell cycle is blocked by multiple mechanisms that inactivate or remove replication proteins after G1 phase. Consistent with the prevailing notion that these mechanisms are redundant, we previously showed that ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-03-17 | GSE4181 | GEO
GenomicsGenome-wide Analysis of Re-replication Reveals Inhibitory Controls that Target Multiple Stages of Replication Initiation
DNA replication must be tightly controlled during each cell cycle to prevent unscheduled replication and ensure proper genome maintenance. The currently known controls that prevent re-replication act redundantly to inhibit pre-Replicative Complex (pre-RC) assembly outside of the G1 phase of the cell...
ORGANISM(S): Saccharomyces cerevisiae 
2006-03-20 | GSE4487 | GEO
TranscriptomicsRe-replication generates whole-chromosomal instability and anueploidy
Aneuploidy, a hallmark of cancer, often arises from whole chromosome instability (W-CIN). Many cancers exhibiting W-CIN, however, show no direct insult to the mitotic proteins that ensure proper segregation of chromosomes. This has stimulated interest in identifying defects in non-mitotic process...
ORGANISM(S): Saccharomyces cerevisiae 
2014-07-25 | E-GEOD-55641 | biostudies-arrayexpress
TranscriptomicsDNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis.
The relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutation of the H3K27 methyltransferase genes, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, result in re-replication (repeated origin firing within the same cell cycle). He...
ORGANISM(S): Arabidopsis thaliana 
2012-08-07 | GSE38286 | GEO
Sort   by:  
 Page size