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ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
UnknownReactive centre loop dynamics and serpin specificity.
Not available
S-EPMC6405850 | biostudies-literature
TranscriptomicsExpression data from human lymphoma endothelium and reactive lymph node-derived endothelium
Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mec...
ORGANISM(S): Homo sapiens 
2010-01-14 | E-GEOD-19882 | biostudies-arrayexpress
UnknownThe stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop.
Not available
S-EPMC4556959 | biostudies-literature
UnknownReactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
Not available
S-EPMC3691886 | biostudies-literature
UnknownReactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication.
Not available
S-EPMC9604144 | biostudies-literature
UnknownPhage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin.
Not available
S-EPMC3888415 | biostudies-literature
UnknownX-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Not available
S-EPMC1500978 | biostudies-literature
UnknownPosition-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin.
Not available
S-EPMC10784704 | biostudies-literature
UnknownCorrection: Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin.
Not available
S-EPMC7482966 | biostudies-literature
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