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TranscriptomicsEssential roles for the splicing regulator nSR100/SRRM4 during nervous system development
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not completely understood. To address these questions...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-65818 | biostudies-arrayexpress
TranscriptomicsMuscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming II
Previous investigations of the core gene regulatory circuitry that controls embryonic stem cell (ESC) pluripotency have largely focused on the roles of transcription, chromatin and non- coding RNA regulators. Alternative splicing (AS) represents a widely acting mode of gene regulation, yet its role ...
ORGANISM(S): Homo sapiens 
2013-06-26 | E-GEOD-45504 | biostudies-arrayexpress
GenomicsHistone H3K4 Demethylation is Negatively Regulated by Histone H3 Acetylation in S. cerevisiae
Histone H3 lysine 4 tri-methylation (H3K4me3) is a hallmark of transcription initiation, but how H3K4me3 is demethylated during gene repression is poorly understood. Jhd2, a JmjC domain protein, was recently identified as the major H3K4me3 histone demethylase (HDM) in S. cerevisiae. While JHD2 is ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-05 | E-GEOD-41424 | biostudies-arrayexpress
TranscriptomicsMuscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I
Previous investigations of the core gene regulatory circuitry that controls embryonic stem cell (ESC) pluripotency have largely focused on the roles of transcription, chromatin and non- coding RNA regulators. Alternative splicing (AS) represents a widely acting mode of gene regulation, yet its role ...
ORGANISM(S): Mus musculus 
2013-06-26 | E-GEOD-45503 | biostudies-arrayexpress
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
TranscriptomicsTranscriptomic analysis of autistic brain reveals convergent molecular pathology [high-throughput sequence data]
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition characterized by marked genetic heterogeneity. Thus, a fundamental question is whether autism represents an aetiologically heterogeneous disorder in which the myriad genetic or environmental risk factors pertur...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-30573 | biostudies-arrayexpress
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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