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GenomicsCheckpoint receptor TIGIT expressed on Tim-1+ B cells regulates tissue inflammation
Checkpoint receptor TIGIT expressed on Tim-1+ B cells regulates tissue inflammation
PRJNA633580 | ENA
TranscriptomicsDirect regulation of T cell exhaustion by NFAT [RNA-Seq]
During persistent antigen stimulation, CD8+ cytolytic T cells (CTL) show a gradual decrease in effector function, or “exhaustion”, which impairs the immune response to tumors and infections. Here we show that NFAT, a transcription factor with an established role in T cell activation, in parallel con...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-64408 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of flies over-expressing cabut protein or RNAi against cabut mRNA
CbtOE (Tim-gal4; UAS-cbtFLAG), Tim-gal4 (control for CbtOE), cbtRNAi (Tim-gal4-UAS-Dcr2-UAS-cbtIR-cbtE1) and Tim-gal4;UAS-Dcr2 (control for CbtRNAi) flies. Flies were entrained in LD (light: dark) condition for 3-4 days and harvested at six time points: ZT3, ZT7, ZT11, ZT15, ZT19, ZT23 Fly heads we...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-67590 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of fly expressing cabut RNAi after exposure to different levels of sucrose
Control (+/cbtE1-UAS-cbt RNAi) or cabut RNAi flies (Tim-gal4, UAS-cbt RNAi) were starved for 16 hours and then exposed to food containing different concentrations of sucrose: 0, 25, 50 and 100 % for 18 hours. Fly heads were collected, RNA was extracted and RNA-seq libraries were prepared as prev...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-58854 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of peripheral CD4+ T cells in the context SARS-CoV-2 infection
CD4+ T cells play a fundamental role in host defenses against viruses by orchestrating B cell development and/or by directly targeting pathogens. This dataset aimed at understanding the molecular profile of CD4+ T cells in the context of an acute and severe SARS-CoV-2 infection. The analyzed patient...
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-13321 | biostudies-arrayexpress
TranscriptomicsRNA-seq of effector (CD43+) CD8+ T cells, CD45+ hematopoietic cells and CD45- tumor/stromal cells from mice bearing bilateral AT-3 tumors following radio-immunotherapy of which one tumor was irradiated
Radiotherapy (RT) destroys tumor cells, which may lead to release of antigens and immune-activating signals. In this way, RT may act as an in situ vaccine and kick-start a T-cell response against the tumor. Immunotherapy enhances tumor-specific T-cell responses. Combination of radiotherapy and immun...
ORGANISM(S): Mus musculus 
2019-02-12 | E-MTAB-6914 | biostudies-arrayexpress
GenomicsSwi1/Timeless prevents repeat instability at fission yeast telomeres
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments present throughout the genome. The fork protection co...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-25 | E-GEOD-74487 | biostudies-arrayexpress
TranscriptomicsEffect of Tcf7l2 Knockout in the development and identity of Mouse brain Thalamus at embryonic stage E18.5 and P60
The thalamus of the brain acts as a relay station; taking inputs from several parts of the brain and then sending the information to the cortex and vice versa. It is also the structure know to affected in several brain developmental disorders such as schizophrenia, autism spectrum disorders, bipolar...
ORGANISM(S): Mus musculus 
2020-02-10 | E-MTAB-8755 | biostudies-arrayexpress
GenomicsGenome-wide maps of Tamoxifen resistance MCF7 cell line
We report the ER alpha regulatory network of Tamoxifen resistance MCF7 cell line using the Chromatin immunoprecipitated high-throughput sequencing technology (ChIP-seq). By Integrating the gene expression data (previously reported) with the ChIP-seq data, we generated ER alpha regulatory network and...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-26083 | biostudies-arrayexpress
UnknownFull-Length Transcriptome Maps of Reef-Building Coral Illuminate the Molecular Basis of Calcification, Symbiosis, and Circadian Genes.
Not available
S-EPMC9570262 | biostudies-literature
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