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TranscriptomicsHuman pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease
Trophoblast is the primary epithelial cell type in the placenta, a transient organ required for proper fetal growth and development. We have identified a CDX2+/p63+ cytotrophoblast (CTB) subpopulation in the early post-implantation human placenta, which is significantly reduced later in gestation. C...
ORGANISM(S): Homo sapiens 
2016-06-16 | E-GEOD-76090 | biostudies-arrayexpress
TranscriptomicsPharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Withaferin A isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied in epithelial-l...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-53049 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30029 | biostudies-arrayexpress
TranscriptomicsICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer
Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeu...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-36924 | biostudies-arrayexpress
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