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TranscriptomicsTrophoblast-Induced Changes in C-X-C Motif Chemokine 10 Expression Contribute to Vascular Smooth Muscle Cell Dedifferentiation During Spiral Artery Remodeling
Endothelial cell and vascular smooth muscle cell were cocultured in hanging droplets to form spheroids representing an inverted vessel lumen. Control or conditioned media from an extravillous trophoblast (EVT) cell line was incubated with vascular spheroids for 24 hours. Spheroid RNA was then analyz...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-MTAB-1462 | biostudies-arrayexpress
GenomicsGenome-wide map of GATA6 DNA binding in human PDAC cells
By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide ...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47535 | biostudies-arrayexpress
GenomicsGenome-wide map of Gata6 DNA binding in mouse pancreas
We have previously described in mouse models that pancreas-specific deletion of Gata6 results in pancreas alterations by rendering pancreatic acinar cells in a non-fully differentiation state, and furthermore it accelerates tumor initiation and progression in a pro-tumorigenic context (KrasG12V exp...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-57090 | biostudies-arrayexpress
GenomicsBPTF is required for c-MYC-induced remodelling of target chromatin and transcriptional activation [ChIP-Seq]
The c-MYC oncogene is a key transcription factor deregulated in most human tumors. Histone marks associated with transcriptionally active genes in euchromatic islands define the set of high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are not known but likely involve...
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-65544 | biostudies-arrayexpress
UnknownExpression of Different Isoforms of Versican During the Development of Mouse Mandibular First Molars.
Not available
S-EPMC6598129 | biostudies-literature
TranscriptomicsRecurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [GPL6984]
STAG2 is a novel UBC tumor suppressor acting through mechanisms that are different from its role to prevent aneuploidy Gene copy number analyses of STAG2 in urinary bladder tumors. R values were extracted from beadstudio and normalised using the pounds method. Log R Ratios were calculated using an a...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51589 | biostudies-arrayexpress
TranscriptomicsRecurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [GPL6983]
STAG2 is a novel UBC tumor suppressor acting through mechanisms that are different from its role to prevent aneuploidy Gene copy number analyses of STAG2 in urinary bladder tumors. R values were extracted from beadstudio and normalised using the pounds method. Log R Ratios were calculated using an a...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51640 | biostudies-arrayexpress
UnknownFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.
Not available
S-EPMC4909985 | biostudies-literature
UnknownThe UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Not available
S-EPMC4470036 | biostudies-literature
UnknownDoes a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians.
Not available
S-EPMC12742085 | biostudies-literature
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