Genome-wide map of Gata6 DNA binding in mouse pancreas

ABSTRACT: We have previously described in mouse models that pancreas-specific deletion of Gata6 results in pancreas alterations by rendering pancreatic acinar cells in a non-fully differentiation state, and furthermore it accelerates tumor initiation and progression in a pro-tumorigenic context (KrasG12V expression). We aim to determine the sites where Gata6 binds at the genome-wide level in the pancreas to unveil why its loss leads to altered pancreatic function and enhanced tumor formation when coexpressed with KrasG12V. Gata6 ChIP-Seq in the mouse pancreas

ORGANISM(S): Mus musculus

SUBMITTER: Francesc Madriles 

PROVIDER: E-GEOD-57090 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress