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MetabolomicsStandardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry
Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant metabolic information, its introduction into routine clinical practice remains a challenge. Among all the different analytical techniques available to interrogate exhaled breath, secondary electrospray ionizat...
2020-01-11 | MTBLS842 | MetaboLights
MetabolomicsOn-line targeted metabolomics for real-time monitoring of relevant compounds in fermentation processes
Fermentation monitoring is a powerful tool for bioprocess development and optimisation. On-line metabolomics is a technology that is starting to gain attention as a bioprocess monitoring tool, allowing the direct measurement of many compounds in the fermentation broth at a very high time resolution....
2024-03-05 | MTBLS7889 | MetaboLights
MetabolomicsAspSnFR: A Genetically-Encoded Biosensor for Real-Time Monitoring of Aspartate in Live Cells

Aspartate is crucial for nucleotide synthesis, ammonia detoxification and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate concentrations in real time and in live cells. We intr...

2024-08-27 | MTBLS10035 | MetaboLights
MetabolomicsRapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites
Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that Secondary Electro-Spray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) can be used as a diagnostic tool for rapid detection of bacterial ...
2022-07-06 | MTBLS5085 | MetaboLights
MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Simulated)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS235 | MetaboLights
MetabolomicsSeawater Analysis by Ambient Mass Spectrometry-Based Seaomics

A transmission mode-direct analysis in real time-quadrupole time of flight-mass spectrometry (TM-DART-QTOF-MS)-based analytical method coupled to multivariate statistical analysis was developed to interrogate lipophilic compounds in seawater samples without the need of desalin...

2020-05-19 | MTBLS1198 | MetaboLights
ProteomicsThe GlycoPaSER prototype as a real-time N-glycopeptide identification tool based on the PaSER parallel computing platform
Real-time database searching allows for simpler and automated proteomics workflows as it eliminates technical bottlenecks in high throughput experiments. Most importantly, it enables results dependent acquisition (RDA) where search results can be used to guide data acquisition during acquisition. Th...
ORGANISM(S): Homo sapiens (Human) 
2023-03-13 | PXD040716 | Pride
Paser Glycoproteomics Glycopaser Results dependent acquisition (rda) Real-time search 
ProteomicsSensitive neoantigen discovery by real-time mutanome-guided immunopeptidomics
Targeting cancer-specific HLA-peptide complexes is a promising immunotherapy approach, with mutated neoantigens offering high value for their immunogenicity and cancer-specificity. Selecting immunogenic targets requires personalized prioritization of cancer-specific immunopeptides. Mass spectrometry...
ORGANISM(S): Homo sapiens (Human) 
2025-06-20 | PXD059824 | Pride
Immunopeptidomics Real-time searches Antigen discovery 
ProteomicsMealTime-MS: A Machine Learning-Guided Real-Time Mass Spectrometry Analysis for Proteomics
Mass spectrometry-based proteomics technologies are the prime methods for the high-throughput identification of proteins expressed in complex biological samples. Nevertheless, mass spectrometry’s technical limitations still hinder its ability to identify low abundance proteins in complex samples. Ch...
ORGANISM(S): Homo sapiens (Human) 
2020-10-27 | PXD017673 | Pride
Human Cell line Hek293 Lc-ms/ms 
ProteomicsFull-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.
Multiplexed quantitative analyses of complex proteomes enable deep biological insight. While a multitude of workflows have been developed for multiplexed analyses, the most quantitatively accurate method (SPS-MS3) suffers from long acquisition duty cycles. We built a new, real-time database search (...
ORGANISM(S): Homo sapiens (Human) 
2020-04-09 | PXD017823 | Pride
Multiplexed Orbiter Real-time search 
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