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MetabolomicsClostridium butyricum MIYAIRI 588-induced protectin D1 has an anti-inflammatory effect on antibiotic-induced intestinal disorder
Metabolites are thought as the end products in cellular regulatory processes and their levels show the strongest relationships with the phenotype. Previously, we showed that the administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated protectin D1, an anti-inflammatory lipid metabol...
2020-10-14 | MTBLS2087 | MetaboLights
MetabolomicsAberrant accumulation of cyclin D1 rewires glutamine metabolism via loss of IDH3 generating metabolic vulnerability in ESCC and HNSCC

Excessive cyclin D1 accumulation is a frequent oncogenic event in head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC). Although classically associated with enhanced proliferation and genomic instability, we reveal that cyclin D1 dysregulation induces unexpe...

2026-08-24 | MTBLS13687 | MetaboLights
TranscriptomicsTranscriptome analysis of SOX9 over-expressing NT2/D1 cells
To identify novel downstream target genes of SOX9, transcriptome analysis of SOX9 transfected human embryonic testicular cell line, NT2/D1, was carried out.
ORGANISM(S): Homo sapiens 
2015-04-30 | E-MTAB-3378 | biostudies-arrayexpress
MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
GenomicsTranslatome analysis of dorsal striatum D1-medium spiny neurons (D1-MSNs) lacking the TrkB receptor in mice.
Translatome analysis of dorsal striatum D1-medium spiny neurons (D1-MSNs) lacking the TrkB receptor in mice.
PRJNA609943 | ENA
ProteomicsSerial recruitment of protein kinase A in the striatum and in the prefrontal cortex mediates the inverted-U shaped dose-response curve of D1 agonists on memory capacity.
This study investigates how D1 dopamine receptor agonists affect working memory capacity (WMC) in mice. WMC, the ability to remember a limited number of elements briefly (roughly 6 objects in humans and mice), is crucial for cognitive function and is impaired in schizophrenia. Dopamine, acting throu...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045107 | Pride
Dopamine Receptor d1 Pka 
ModelsYapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons
Yapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons This model is described in the article: Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. Yapo C, Nair AG, Clement L, Castro LR, Hellgren Kotaleski J, Vincent P. J. Phy...
2017-08-16 | MODEL1701170000 | BioModels
TranscriptomicsGene expression change in cyclin D1 -/- retinas in comparison to wildtype.
Cyclin D1 belongs to the core cell cycle machinery1, and it is frequently overexpressed in human cancers2. The full repertoire of cyclin D1 functions in normal development and in cancer cells is currently unknown. To address this question, here we introduce a novel approach that allows one to deter...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-13635 | biostudies-arrayexpress
TranscriptomicssiRNA-mediated knockdown of VAMP7 in NTERA2/D1 cells
To unravel the function of VAMP7 in the male sexual differentiation, we carried out in vitro studies of VAMP7 knockdown using siRNA, in the human embryonal carcinoma NTERA2/D1 cells. We knocked down VAMP7 expression in the testicular teratocarcinoma cell line, NTERA2/D1. By comparing the knockdown c...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56102 | biostudies-arrayexpress
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