Sort   by:  
 Page size 
MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
TranscriptomicsSingle cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes
Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to model Parkinson’s disease (PD) but neuronal cultures are confounded by cellular heterogeneity. By applying high-resolution single cell transcriptomic analyses to Parkinson’s iPSC-derived dopamine neurons carrying...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7303 | biostudies-arrayexpress
TranscriptomicsMethylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
Background: Methylphenidate (MPH) a psychostimulant prescribed to manage ADHD symptoms, has been increasingly prescribed to children not meeting the strict criteria for ADHD. It has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whet...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-33619 | biostudies-arrayexpress
TranscriptomicsNrf2-related oxidative stress response and impaired dopamine biosynthesis in a PC12 cell model of Huntington’s disease
Huntington’s disease (HD) is a devastating disease for which currently no therapy is available. It is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD gene, resulting in an expansion of polyglutamines at the N-terminal end of the encode...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-10581 | biostudies-arrayexpress
ModelsBest2009 - Homeostatic mechanisms in dopamine synthesis and release
Best2009 - Homeostatic mechanisms in dopamine synthesis and release Encoded non-curated model. Issues: - Initial concentrations for hva, tyrpool, NADPH and NADP are missing - Reaction VMAT requires two substrates to match the formula proposed in the article This model is de...
2015-04-15 | MODEL1502230000 | BioModels
TranscriptomicsTransitions in infant learning are modulated by dopamine within the amygdala
Behavioral transitions Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray results showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Cortico...
ORGANISM(S): Rattus norvegicus 
2009-09-27 | E-GEOD-17651 | biostudies-arrayexpress
ProteomicsThe involvement of dopamine in the post-translational modification of proteins in sponges
Sponges are the organisms unique for their lack of specialized nerve cells and classical monoamine receptors. Sponges are a highly symbiotic organism, and bacteria make a significant contribution to their biochemical processes. The aim of our project is to investigate the involvement of dopamine in ...
ORGANISM(S): Halisarca dujardinii 
2025-11-06 | PXD066419 | Pride
Dopamine Lc-msms Sponges Proteome 
TranscriptomicsNurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Nurr1 (Nr4a2, nuclear receptor subfamily 4 group A member 2) is needed for the development of ventral midbrain dopaminergic neurons, and has been associated with Parkinson's disease. We used mice where the Nurr1 gene is ablated by tamoxifen treatment selectively in dopaminergic neurons. As a control...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-42912 | biostudies-arrayexpress
GenomicsDopamine biosynthesis in plants
Dopamine biosynthesis in plants
PRJNA1197496 | ENA
ModelsYapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons
Yapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons This model is described in the article: Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. Yapo C, Nair AG, Clement L, Castro LR, Hellgren Kotaleski J, Vincent P. J. Phy...
2017-08-16 | MODEL1701170000 | BioModels
Sort   by:  
 Page size