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TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
ProteomicsProteomic profiling by array of tyrosine kinase activity in metastatic malignant melanoma from human tissue specimens
Tyrosine kinase activity profiling of metatstatic malignant melanoma and normal skin tissue samples was performed using peptide kinase arrays. All samples were run in triplicates with and withouth inhbitor PLX4032 and Sutent Malate in order to identify how tyrosine kinases responds to kinase inhibit...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1245 | biostudies-arrayexpress
ProteomicsEarly Signaling Dynamics of EGFR
Despite extensive study of the epidermal growth factor receptor (EGFR) signaling network, the immediate post-translational changes that occur in response to growth factor stimulation remain poorly characterized; as a result, the biological mechanisms underlying signaling initiation remain obscured. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080800 | MassIVE
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the MLL-AF4 and Flt3 tyrosine kinase domain (TKD) genes in 32Dc cell
The tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Flt3 gene mutation in the tyrosine kinase domain (TKD) was observed in approximately 15% of MLL leukemia, we investigated synergistic leukemogenesis effects of the two genes in vitro. In a ...
ORGANISM(S): Mus musculus 
2009-03-31 | E-GEOD-14236 | biostudies-arrayexpress
TranscriptomicsMembranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor (EGFR) Predicts Outcome after Chemoradiotherapy of Lymph Node Negative Cervical Cancer
We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full length receptor and its autophosphorylation status in cervical cancers treated with conventional chemoradiotherapy. We furt...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29817 | biostudies-arrayexpress
TranscriptomicsIdentification of common features proffered by KIT and PDGFRA mutations in gastro-intestinal stromal tumors
Mutations in KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet derived growth factor receptor alpha (PDGFRA) are responsible for more than 85% of the gastrointestinal stromal tumors (GIST). The introduction of imatinib in the therapy scheme of GIST revolutionized the patient outcome. Unf...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4548 | biostudies-arrayexpress
ProteomicsProtein tyrosine kinases analysis by multiplexed parallel reaction monitoring assays
In this study, we have developed a parallel reaction monitoring (PRM)-based assay for quantitative profiling of 83 PTKs. The assay detects 308 proteotypic peptides from 54 receptor tyrosine kinases and 29 nonreceptor tyrosine kinases in a single run. We used this assay to determine PTKs in lung canc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-12 | MSV000079224 | MassIVE
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
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