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ProteomicsProtein tyrosine kinases analysis by multiplexed parallel reaction monitoring assays
In this study, we have developed a parallel reaction monitoring (PRM)-based assay for quantitative profiling of 83 PTKs. The assay detects 308 proteotypic peptides from 54 receptor tyrosine kinases and 29 nonreceptor tyrosine kinases in a single run. We used this assay to determine PTKs in lung canc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-12 | MSV000079224 | MassIVE
TranscriptomicsTranscription profiling of mouse 32Dcl3 cell lines expressing oncogenic tyrosine kinases or cells treated with small molecule inhibitors
Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGF-beta-R and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They activate many of the same signal transduction pathways. To identify the critical target genes required for transformation in hematopoietic cells...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11794 | biostudies-arrayexpress
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
GenomicsReceptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [RNA-seq]
Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [RNA-seq]
PRJNA837230 | ENA
TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
ProteomicsTyrosine phosphoproteomics of patient-derived xenografts reveals ephrin type-B receptor 4 tyrosine kinase as novel therapeutic target in pancreatic cancer
Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, discovery of aberrantly a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-24 | PXD021729 | Pride
Receptor tyrosine kinase Ptyr Pdx Signaling Cancer 
GenomicsReceptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [ChIP-seq]
Receptor Tyrosine Kinases phosphorylate RNA polymerase II at signal-responsive genes [ChIP-seq]
PRJNA837229 | ENA
ProteomicsThe landscape of phospho-tyrosine mediated protein interactions of human receptor tyrosine kinases
Systematically profiling the interactome of 1,144 unique wild-type and mutant phosphotyrosine residues of receptor tyrosine kinases by affinity enrichment - mass spectrometry (AE-MS), followed by a subset of novel interactors validation by competition assay.
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD015927 | Pride
Tyrosine phosphorylation Ptb domain Receptor tyrosine kinases Phosphotyrosine interacting domain Affinity enrichment-mass spectrometry Hot-spot mutation Cell signaling Protein-protein interaction Mutation‐gain tyrosine Sh2 domain Interactome 
ProteomicsCharacterization of the interactome of receptor tyrosine kinase proline rich motifs
Here we explore the interactome of the proline-rich motif regions of non-activated receptor tyrosine kinases by affinity purification mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2024-10-01 | PXD041383 | Pride
Human Cancer Receptor tyrosine kinase 
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
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