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MetabolomicsFatal COVID-19 pulmonary disease involves ferroptosis.

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
ProteomicsInvestigation of IgG-reactivity Profiles and Epitope Landscape in Divergent COVID-19 Trajectories and SARS-CoV-2 Variants using SARS-CoV-2 whole proteome peptide microarray
The objective of the study was to characterize the immunoreactivity profiles of IgG-reactive epitopes in COVID-19 patients with distinct disease trajectories as well as SARS-CoV-2-naïve sera, using a high-density SARS-CoV-2 whole proteome peptide microarray. The microarray comprised of a total of 53...
ORGANISM(S): Homo sapiens 
2025-03-31 | E-MTAB-14495 | biostudies-arrayexpress
ProteomicsTargeted validation of significantly altered semen proteins in COVID-19 patients
The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long...
ORGANISM(S): Homo Sapiens 
2022-06-26 | PXD026849 | panorama
ProteomicsSerum proteomics in a cohort of COVID patients and healthy controls
This project investigates the serum proteome patterms in recovered COVID patients compared to that in healthy controls. Specifically, serum saamples from 29 recovered patients and 29 age, sex, and race matched healthy controls were collected and subject to DIA-MS proteomics. A fraction of the serum ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD036597 | Pride
Dia-ms Serum proteomics Recovered covid patients Healthy controls 
ProteomicsA longitudinal study of COVID-19 patients using proteomics approach
SARS-CoV-2, a highly contagious and infectious virus is responsible for causing this COVID-19 pandemic, which has a substantial impact on global health and economy. The spectrum of clinical manifestations of COVID-19 ranges from mild or non-severe state to severe life-threatening condition in some g...
ORGANISM(S): Homo sapiens (Human) 
2021-05-27 | PXD023521 | Pride
Sars-cov2 Severe vs non-severe Human Plasma Proteomics Covid-19 Lc-ms/ms 
ProteomicsPlasma-derived Exosome-Like Vesicles (ELVs) of COVID-19 patients expose SARS-CoV-2-Spike-derived fragments and contribute to the adaptive immune response
COVID-19 is an infectious disease caused by beta-coronavirus SARS-CoV-2 which has rapidly spread across the globe starting from February 2020. It is well established that during viral infection extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding ex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD029007 | Pride
Exosome-like vesicles (elvs) Covid-19 Lcmsms 
ProteomicsQuantitative serum proteomic analysis for potential biomarkers in post-COVID-19 onset Postural Orthostatic Tachycardia Syndrome (PC-POTS) patients
Postural orthostatic tachycardia syndrome (POTS) is a chronic neurological disorder of the autonomic nervous system (ANS) that is characterized by an excessive increase in heart rate upon orthostatic challenge. The symptoms of POTS are often debilitating, and it primarily affects young females. Even...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD052725 | Pride
Post-acute sequelae of covid-19 Post-covid-19 syndrome Mass spectrometry Postural orthostatic tachycardia syndrome Long covid syndrome Tandem mass tag Serum proteomics Biomarker 
GenomicsNasopharyngeal microbiome analysis in the healthy, recovered and demised COVID-19 patients from Gujarat, India
Nasopharyngeal microbiome analysis in the healthy, recovered and demised COVID-19 patients from Gujarat, India Raw sequence reads
PRJNA763288 | ENA
ProteomicsCOVID-19 PATIENTS WITH NEUROLOGICAL SYMPTOMS PRESENT BROAD CENTRAL NERVOUS SYSTEM MOLECULAR AND STRUCTURAL ALTERATIONS ASSOCIATED WITH SYSTEMIC INFLAMMATION AND DISEASE SEVERITY
Background. COVID-19-induced neurological disease is a growing concern. Here we provide a comprehensive clinical, molecular, and neuroimaging investigation of patients presenting neurological symptoms to investigate underlying processes. Methods. We performed a detailed systematized clinical, labor...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD033979 | Pride
Cerebrospinal fluid Csf Inflammation Prorteomics Covid-19 
ProteomicsSARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms and are associated with altered cerebral cortical thickness. Using an independent cohort...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD023781 | Pride
Covid-19 Astrocytes Proteomics Sars-cov2 
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