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Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights

This study aimed to investigate systemic metabolic alterations underlying pain-depression comorbidity in the Recurrent Pelvic Pain (RPP) rat model using untargeted serum metabolomics (UPLC-Q-Orbitrap-MS). Comparative analysis revealed distinct metabolic profiles, identifying 234 differential meta...

2026-02-11 | MTBLS13869 | MetaboLights

Gestational diabetes mellitus (GDM) is a common complication of pregnancy, particularly affecting multiparous women with a history of GDM, who face a recurrence risk approaching 50%. This study investigates the association between gut microbiota modifications and metabolic profiles from early to ...

2025-07-21 | MTBLS12326 | MetaboLights
Not available
ORGANISM(S): Homo sapiens 

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
Not available
ORGANISM(S): Rattus norvegicus 
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. ...
ORGANISM(S): Rattus norvegicus 
Background: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. Methods: We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC in vivo using replicate LongSAGE libraries. We refer ...
ORGANISM(S): Homo sapiens 
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