Sort   by:  
 Page size 
MetabolomicsReduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance
Not available
ORGANISM(S): Homo sapiens 
ST002054 | MetabolomicsWorkbench
MetabolomicsCholesterol metabolism regulates cartilage metabolic-inflammatory crosstalk by triggering osteocyte mitochondria transfer as a therapeutic target for osteoarthritis
Osteoarthritis (OA) is considered as a metabolic related inflammatory disease in the joint affecting both cartilage and subchondral bone. Cholesterol metabolism has been implicated in the pathogenesis of OA, yet the underlying mechanism still remains elusive. Understanding the role of cholesterol me...
2025-09-28 | MTBLS11733 | MetaboLights
TranscriptomicsHuman mitochondria hub of small RNAs: Analysis by deep Sequencing
We report here that human mitochondria contain small RNA including microRNA, piRNA, tRNA, rRNA, and RNA repeats. Mitochondria from human cells were purified and RNA isolated. Small RNAs were purified, library generated and analyzed by Illumina Hiseq 2000 system. The sequencing generated 19.5 and 17....
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-32185 | biostudies-arrayexpress
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsHydrolyzing NAD to NMN and AMP by SelO is required for mitochondria homeostasis

The regulation of mitochondrial nicotinamide adenine dinucleotide (mNAD) is crucial for numerous life processes. However, until now, no metabolic reaction responsible for downregulating mNAD has been identified. Through in silico screening of potential NAD-binding proteins, we discovered a previo...

2026-01-07 | MTBLS13624 | MetaboLights
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsReduced mitochondria provide an essential function for the cytosolic methionine cycle
Since the discovery of eukaryotes without mitochondria, intestinal flagellates oxymonads, it was clear that the loss of mitochondria was facilitated by the remodelling of the FeS cluster synthesis. Yet, this remodelling is common for a broader linage including free-living species with reduced mitoch...
ORGANISM(S): Paratrimastix pyriformis 
2023-03-11 | PXD033021 | Pride
Reduced mitochondria Glycine cleavage system Paratrimastix Mitochondrial loss Lopit One-carbon metabolism Proteome Methionine cycle 
TranscriptomicsTo analyze the effect of loss of mitochondria on the transcriptome of Candida albicans
This set of experiment was done in order to analyze the effect of a dysfunctional mitochondria on C. albicans. The mutant was obtained by deleting the gene FZO1, which is known to be involved in mitochondrial biogenesis in S. cerevisiae. We show that the deletion of FZO1 leads to a change in mitocho...
ORGANISM(S): Candida albicans 
2013-12-05 | E-GEOD-46003 | biostudies-arrayexpress
ProteomicsComparative proteomic study on liver lipid droplets and mitochondria from mouse housed in different temperatures
Laboratory mice are standardly housed around 23ºC, setting them under chronic cold stress. Metabolic changes of liver in mice housed under thermoneutral, standard and cold temperatures remain unknown. Here we isolated lipid droplets and mitochondria from their livers for comparative proteomic study ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-07-17 | MSV000084105 | MassIVE
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
Sort   by:  
 Page size