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MetabolomicsPhotorespiration is linked to DNA methylation by formate as one-carbon source.
DNA methylation is a key epigenetic modification regulating genome organization, stability, and gene expression. Stable DNA methylation critically relies on methyl groups provided through folate-mediated one-carbon (C1) metabolism, yet the origin and regulation of C1 supply remain elusive. Here we d...
2026-01-06 | MTBLS13444 | MetaboLights
ProteomicsMetabolic control of DNA methylation and imprinted gene expression in naive pluripotent cells
Naive pluripotent epiblast cells of the preimplantation murine embryo and their in vitro counterpart, embryonic stem (ES) cells, have the capacity to give rise to all cells of the adult. Such developmental plasticity is associated with global genome hypomethylation. It is unclear whether genome meth...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-26 | PXD020385 | Pride
Dna methylation Tet Es Dnmts 
UnknownReductive methylation to improve crystallization of the putative oxidoreductase Rv0765c from Mycobacterium tuberculosis.
Not available
S-EPMC2335070 | biostudies-literature
UnknownDeaminative Reductive Methylation of Alkylpyridinium Salts.
Not available
S-EPMC8448964 | biostudies-literature
UnknownApplication of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.
Not available
S-EPMC6270119 | biostudies-literature
ProteomicsMethylated-antibody affinity purification to improve proteomic identification of plant RNA polymerase Pol V complex and the interacting proteins
Affinity purification followed by enzymatic digestion and mass spectrometry has been widely utilized for the sensitive detection of interacting proteins and protein complexes in various organisms. In plants, the method is technically challenging due to the low abundance proteins, non-specific bindin...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-02-28 | PXD005422 | Pride
On-bead digestion Pol v complex Chemical cross-link Reductive methylation Ap-ms 
UnknownReductive methylation and mutation of an anthrax toxin fusion protein modulates its stability and cytotoxicity.
Not available
S-EPMC3996465 | biostudies-literature
UnknownMesoionic N-heterocyclic olefin catalysed reductive functionalization of CO2 for consecutive N-methylation of amines.
Not available
S-EPMC8457391 | biostudies-literature
ProteomicsSystematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylation
Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its demonstrated importance in development, disease, and cancer, the molecular agents responsible for the deposition of H3K36me are not yet well under...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-05 | MSV000093049 | MassIVE
UnknownSalvage of failed protein targets by reductive alkylation.
Not available
S-EPMC4078742 | biostudies-literature
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