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TranscriptomicsThe miRNA miR-139-5p is a regulator of metastatic pathways in breast cancer.
Whole transcriptome Identification of direct targets of miR-139-5p using biotinylated pull-downs found that this miRNA has roles in breast cancer invasion and migration. MCF7 cells were transfected with biotinylated miR-139-5p. The miRNAs and target mRNA were pulled down with streptavidin and compa...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-40411 | biostudies-arrayexpress
TranscriptomicsImperfect centered miRNA binding sites are common and can mediate functional repression of target mRNAs.
Whole transcriptome Identification of direct targets identify a new class of miRNA::mRNA interactions. HEK293T cells were transfected with biotinylated miRNAs. The miRNAs and target mRNA were pulled down with streptavidin and compared to a mock transfected control.
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-40408 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide target profiling for miR-199a-5p and miR-424-3p.
Whole transcriptome Identification of direct targets of miR-199a-5p and miR-424-3p using biotinylated pull-downs found that both miRNAs are likely to have a role in the cell cycle. HEK293T cells were transfected with biotinylated miRNAs (either miR-199a-5p or miR-424-3p). The miRNAs and target mRNA...
ORGANISM(S): Homo sapiens 
2013-12-02 | E-GEOD-40406 | biostudies-arrayexpress
TranscriptomicsDecorin and EphA2 mediate Carcinoembryonic Antigen Cell Adhesion Molecule 1-L inhibition of colorectal cancer metastasis
Objective We have previously shown that expression of the CEACAM1 long isoform (CC1-L) in metastatic colorectal cancer (CRC) cells results in significant inhibition of liver metastasis via Chemokine (C-C motif) Ligand 2 (CCL2) and Signal Transducer and Activator of Transcription 3 (STAT3) signaling...
ORGANISM(S): Mus musculus 
2015-09-19 | E-GEOD-73208 | biostudies-arrayexpress
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