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TranscriptomicsGenomic profile of foamy and non-foamy granuloma macrophages from fat-fed ApoE null mice or control mice fed a normal diet
Formation of foam cell macrophages (FCMs), which sequester extracellular modified lipids, is a key event in atherosclerosis. How lipid loading affects macrophage phenotype is controversial, with evidence suggesting either pro- or anti-inflammatory consequences. To investigate this further, we compar...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-70126 | biostudies-arrayexpress
TranscriptomicsIdentification of genes characteristic of committed preadipocyte fibroblasts
In order to identify the molecular mechanisms controlling preadipocyte commitment we derived new sublines of Swiss 3T3 fibroblasts with varying potential for adipogenesis. Swiss 2, Swiss 8, Swiss 9, and Swiss 19 differentiate into fat cells while Swiss 3, Swiss 5, and Swiss 22 have a lower propensi...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-19732 | biostudies-arrayexpress
UnknownNew insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.
Not available
S-EPMC6537940 | biostudies-literature
TranscriptomicsGene expression patterns and TP53 mutations are associated with HPV RNA status, lymph node metastasis, and survival in head and neck cancer
A growing proportion of head and neck squamous cell carcinomas (HNSCC) is associated with the human papilloma virus (HPV), particularly HPV16. We compare tumors with different HPV16 DNA and RNA (E6*I) status from 290 consecutively recruited HNSCC patients by gene expression profiling and targeted se...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-65858 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling in TPC1 cell line treated with the RTK inhibitor RPI-1
We treated the papillary thyroid carcinoma-derived cell line TPC1 with the RTK inhibitor RPI-1 to obtain a thyroid carcinoma cell model. The RET tyrosine kinase is a target of the inhibitor. microRNA expression changes were evaluated comparing cells treated with the inhibitor fo 24 hours versus cell...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-49401 | biostudies-arrayexpress
TranscriptomicsMurine study of combined LPS and modified immunoglobulins associated gene expression changes in vivo
We systematically assessed the transcriptomic changes of lipopolysaccharides (LPS) of mice upon stimulation with immunoglobulins (IVIg), modified immunoglobulins (modIVIg) or vehicle controls in kidney, blood and liver in vivo. Data indicate different in vivo responses to LPS in conjunction with IVI...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-55694 | biostudies-arrayexpress
TranscriptomicsInflammatory environment and oxidized LDL convert circulating human proangiogenic cells (PACs) into functional antigen presenting cells (APCs)
The function of human circulating proangiogenic cells (PACs) has been described extensively. However, little focus has been placed on understanding how these cells differ in their functions in the presence of microenvironments mimicking vascular inflammation. We hypothesized that exposure to proinfl...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-60208 | biostudies-arrayexpress
UnknownIs adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93.
Not available
S-EPMC3589110 | biostudies-literature
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