Refractory - OmicsDI

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Unknown (20028)
Genomics (2193)
Transcriptomics (1703)
Clinical (404)
Proteomics (188)
Other (73)
Metabolomics (36)
Methylation profiling (31)
Genomic (16)
Models (12)
Multiomics (3)

Organisms

Homo sapiens (1517)
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Caenorhabditis elegans (42)
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Schizosaccharomyces pombe (12)
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cellular organisms (2)
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Paracoccidioides brasiliensis (2)
mixed sample (2)
Glycine max (2)
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Cavia porcellus (1)
Octopus vulgaris (1)

Organisms

Homo sapiens (984)
Mus musculus (334)
Rattus norvegicus (20)
human gut metagenome (7)
Saccharomyces cerevisiae (6)
Aedes aegypti (4)
Caenorhabditis elegans (4)
Xenopus laevis (3)
gut metagenome (3)
Drosophila melanogaster (2)
Canis lupus familiaris (2)
Candida albicans (2)
Zea mays (2)
Staphylococcus aureus (2)
Danio rerio (2)
Arabidopsis thaliana (2)
Bos taurus (2)
synthetic construct (2)
Rosenbergiella sp. YN46 (1)
Pelagibacterium xiamenense (1)
Emberiza melanocephala (1)
Oncorhynchus gorbuscha (1)
Ixodes pacificus (1)
Streptococcus equinus ATCC 33317 (1)
Nothapodytes nimmoniana (1)
Neurospora intermedia (1)
Rattus rattus (1)
Staphylococcus epidermidis RP62A (1)
Homo sapiens/Mus musculus xenograft (1)
Plasmodium falciparum 3D7 (1)

Repository

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geo (1265)
biostudies-arrayexpress (759)
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pride (119)
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iProX (23)
dbGaP (16)
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PanoramaPublic (3)
NODE (2)
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MetabolomicsWorkbench (1)
PAXDB (1)
PeptideAtlas (1)

Tissue

Cell culture (34)
B cell (9)
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Blood cell (4)
Blood plasma (4)
Leaf (4)
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Blood serum (2)
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Neutrophil (2)
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Type II pneumocyte (2)
Blood (1)
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Prefrontal Cortex (1)
Others (1)
B-cell lymphoma/leukemia 11B (1)
Blood platelet (1)

Disease

Colorectal Neoplasms (149)
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Carcinoma (25)
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Lymphoma (15)
Colorectal cancer (11)
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Neoplasm Metastasis (9)
Adenocarcinoma (8)
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Prostate cancer (4)
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Acute promyelocytic leukemia (3)
Chronic myelogenous leukemia (2)
Normal (2)
Cancer (1)
Hepatitis C virus-induced hepatocellular carcinoma (1)
Acute erythroid leukemia (1)
Ulcerative colitis (1)
Uninfected (1)
Metastatic prostate cancer (1)
Alveolar rhabdomyosarcoma (1)
Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (1)
Colon carcinoma (1)
T-cell acute lymphoblastic leukemia (1)
Embryonal carcinoma (1)
Colorectal adenocarcinoma (1)
Adenocarcinoma (1)
Ewing's sarcoma (1)

Technology Type

Mass Spectrometry (120)
Shotgun proteomics (58)
Affinity purification coupled with mass spectrometry proteomics (27)
Mass spectrometry (25)
Bottom-up proteomics (21)
Data-dependent acquisition (11)
Gel-based experiment (11)
Illumina HiSeq 2500 (6)
Illumina HiSeq 2000 (6)
Mass spectrometry assay (6)
Illumina HiSeq 2500, ILLUMINA (3)
Data-independent acquisition (3)
SWATH MS (3)
Affinity proteomics (2)
HDMSE (2)
Olink affinity proteomics (2)
SNP6, ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, Illumina MiSeq (1)
Illumina HiSeq 2000, Illumina MiSeq (1)
Illumina Genome Analyzer, Illumina HiSeq 2000, Illumina MiSeq, Affymetrix_U133plus2- (1)
Illumina (1)
AB SOLiD 4 System (1)
Illumina MiSeq (1)
Illumina Genome Analyzer II (1)
NMR spectroscopy assay (1)
NMR spectroscopy (1)
ESI (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
Mass spectrometry imaging (1)
Proteogenomics (1)

Instrument Platform

Illumina NovaSeq 6000 (21)
Illumina HiSeq 4000 (14)
NextSeq 500 (13)
Illumina HiSeq 2000 (7)
NextSeq 550 (6)
Illumina HiSeq 2500 (4)
GenePix 4000A [Axon Instruments] (3)
DNBSEQ-G400 (3)
Illumina MiSeq (3)
Illumina HiSeq 1500 (3)
Complete Genomics (2)
DNA Microarray Scanner BA [Agilent Technologies] (2)
None (2)
Ion Chef (2)
NextSeq 2000 (2)
BGISEQ-500 (2)
Ion Torrent S5 XL (2)
Illumina DNA Prep sample preparation kits (Illumina Inc., San Diego, CA, USA). Final libraries concentrations and size were assessed with Quant-IT DNA Assay Kit and Agilent 4200 Tapestation System (Agilent Technologies, Milan, Italy), (1)
QIAamp DNA minikit, Qiagen, Germany (1)
Coulter Automated Workstation Biomek i7 Hybrid (1)
RNeasy 96-well plate kit (1)
10x genomic Chromium controller (1)
Microcentrifuge (1)
IScan (Illumina) (1)
MiniSeq (1)
Typhoon TRIO (1)
AB SOLiD 4 System (1)
Illumina Genome Analyzer IIx (1)
NanoDrop (1)
Bioanalyser (1)

Publication Date

2025 (264)
2026 (236)
2024 (167)
2023 (160)
2022 (148)
2021 (113)
2015 (109)
2020 (104)
2014 (102)
2013 (99)
2017 (92)
2010 (90)
2011 (89)
2012 (84)
2009 (67)
2008 (63)
2018 (62)
2016 (60)
2019 (58)
2007 (39)
2005 (12)
2006 (10)
2004 (8)
2003 (1)
2027 (1)

UNIPROT ID/AC

P42345 (2)
P27986 (2)
P31749 (2)
Q14609 (1)
Q5STB3 (1)
O60346 (1)
Q16543 (1)
P07900 (1)
Q8N6C8 (1)
O00463 (1)
Q15750 (1)
P41279 (1)
Q13077 (1)
Q8N5C8 (1)
Q9NYJ8 (1)
P20333 (1)
Q13114 (1)
Q99558 (1)
Q6R327 (1)
Q8N122 (1)
Q5T1C6 (1)
P56279 (1)
Q12933 (1)
Q15628 (1)
Q13546 (1)
P78527 (1)
P49137 (1)
P49815 (1)
Q92574 (1)
P23443 (1)

ENSEMBL ID

ENSG00000170477 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:16467 (8)
CHEBI:18050 (8)
CHEBI:17203 (7)
CHEBI:16015 (7)
CHEBI:17895 (7)
CHEBI:17295 (7)
CHEBI:506227 (6)
CHEBI:15971 (6)
CHEBI:16347 (6)
CHEBI:16828 (6)
CHEBI:17368 (6)
CHEBI:16708 (5)
CHEBI:16750 (5)
CHEBI:16737 (5)
CHEBI:15603 (5)
CHEBI:17596 (5)
CHEBI:17351 (5)
CHEBI:30769 (5)
CHEBI:17768 (4)
CHEBI:28822 (4)
CHEBI:16450 (4)
CHEBI:17562 (4)
CHEBI:63637 (1)
CHEBI:75047 (1)
CHEBI:79091 (1)
CHEBI:35222 (1)
CHEBI:27732 (1)
CHEBI:18348 (1)
CHEBI:29108 (1)
CHEBI:16618 (1)

Metabolite Name

L-Arginine (10)
L-Glutamine (10)
Hypoxanthine (10)
Adenine (9)
Betaine (8)
Ornithine (8)
Adenosine (8)
L-Tryptophan (8)
Xanthine (8)
L-Phenylalanine (8)
L-Proline (7)
Guanosine (7)
Uridine (7)
Creatinine (7)
Creatine (7)
L-Tyrosine (7)
Uracil (6)
L-Lysine (6)
Hydroxyphenyllactic acid (6)
L-Asparagine (6)
L-Threonine (6)
L-Histidine (6)
Methionine (6)
Xanthosine (6)
Cytosine (6)
Riboflavin (6)
L-Serine (6)
Cytidine (6)
Inosine (6)
5-Methyluridine (5)

First Public Date

2025 (302)
2026 (289)
2024 (211)
2023 (180)
2022 (147)
2021 (128)
2014 (126)
2020 (114)
2017 (91)
2019 (70)
2018 (70)
2015 (40)
2016 (18)
2013 (13)
2012 (1)

Modelling Approach

Ordinary differential equation model (8)
Boolean model (1)
Constraint-based model (1)

Study status

Completed (191)
Recruiting (71)
Active, not recruiting (40)
Terminated (39)
Not provided (28)
Not yet recruiting (17)
Withdrawn (11)
Ongoing (6)
Approved for marketing (1)

Lab affiliation

ETH Zurich (5)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA (3)
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany (2)
Massachusetts Institute of Technology (2)
Moffitt Cancer Center Tampa, FL, USA (2)
School of Life and Environmental Sciences, University of Sydney, NSW Australia (2)
*Dr. Arun Sharma Protein Biochemistry and Structural Biology Division National Institute of Malaria Research (ICMR) Department of Health Research, Ministry of Health and Family Welfare, Govt. of India Sector-8, Dwarka, New Delhi- 110077 (1)
- Platelet Research Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain - Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands - Department of Medicine, University of Oviedo, Oviedo, Spain (1)
1 Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA (1)
1. Translational Immunology Research Program, Transplantation Laboratory, University of Helsinki, Helsinki, Finland. 2. HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland (1)
AMU, CNRS, INSERM, Institut Paoli-Calmettes, CRCM (1)
Aalborg University (1)
AbbVie Bioresearch Center, Worcester, MA 01605, United States (1)
Aix-Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Assistant Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation (1)
Assistant professor, School of Biological Sciences, Seoul National University (1)
Basic Immune System of Plants / Protein Mass Spectrometry Max Planck Institute for Plant Breeding Research Carl-von-Linne-Weg 10, 50829 Cologne, Germany (1)
Boston University School of Medicine (1)
Brown University MCB Department (1)
Cambridge Stem Cell Institute, Cambridge, United Kingdom, CB2 0AW (1)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada (1)
Cancer Biology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University (1)
Cancer Center of Union Hospital, Tongji Medical College,Huazhong University of Science and Technology (1)
Cancer Research UK Scotland Institute (Formerly the Cancer Research UK Beatson Institute) Garscube Estate Switchback Road Bearsden Glasgow, G61 1BD (1)
Cancer Science Institute of Singapore, National University of Singapore (1)
Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Québec, QC, Canada Centre de recherche sur le cancer de l’Université Laval, Québec, QC, Canada PROTEO-Quebec Network for Research on Protein Function, Engineering, and Applications, Québec, QC, Canada Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec, QC, Canada (1)
Chair of Proteomics and Bioanalytics Technical University of Munich Partner Site of the German Cancer Consortium (1)
Chemistry Department, University of Minnesota, United States (1)
Clinical Research Division, Fred Hutchinson Cancer Research Center (1)

Keyword

Irinotecan (30)
Bevacizumab (26)
Cetuximab (26)
Pembrolizumab (23)
Antibodies (20)
Antibodies, Monoclonal (20)
Nivolumab (16)
Immunoglobulins (15)
Metastatic (14)
Capecitabine (14)
Colorectal (13)
Antineoplastic Agents, Immunological (13)
Panitumumab (12)
Fluorouracil (12)
Gemcitabine (11)
Leucovorin (11)
Oxaliplatin (11)
Recurrent mycosis fungoides/Sezary syndrome (10)
Fludarabine (10)
Anaplastic large cell lymphoma (10)
Recurrent colon cancer (10)
Stage IV colon cancer (10)
Immunotherapy (10)
Recurrent adult Burkitt lymphoma (9)
Recurrent adult diffuse large cell lymphoma (9)
Recurrent adult Hodgkin lymphoma (9)
Recurrent cutaneous T-cell non-Hodgkin lymphoma (9)
Recurrent small lymphocytic lymphoma (9)
Recurrent marginal zone lymphoma (9)
Recurrent grade 1 follicular lymphoma (9)

IsPrivate

False (12)

Model Flag

Non Kinetic (1)

Submitter Keywords

Immuno-oncology (2)
Not Peer Reviewed (1)

Classification

bacteria (14)
fungi (3)
protozoa (2)
viruses (1)

Modification

-17.026549 (1)
-18.010565 (1)
0.984016 (1)
15.994915 (1)
2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)
57.021464 (1)
Not available (1)

Study type

Transcription profiling by array (417)
RNA-seq of coding RNA (87)
ChIP-seq (55)
Comparative genomic hybridization by array (36)
Methylation profiling by array (25)
Other (16)
RNA-seq of coding RNA from single cells (16)
RNA-seq of non coding RNA (16)
Unknown experiment type (13)
ChIP-chip by tiling array (13)
DNA-seq (8)
Genotyping by array (7)
ChIP-chip by array (6)
Human - High-throughput sequencing (4)
Transcription profiling by tiling array (4)
MicroRNA profiling by array (4)
Genotyping by high throughput sequencing (4)
RNA-seq of total RNA (4)
RNAi profiling by array (3)
Transcription profiling by RT-PCR (3)
Proteomic profiling by array (3)
Methylation profiling by high throughput sequencing (3)
Human - One-color microarray (2)
ATAC-seq (2)
Transcription profiling by SAGE (1)
MicroRNA profiling by high-throughput sequencing (1)
One-color microarray (1)
High-throughput sequencing (1)
Exome sequencing (1)
RIP-seq (1)

Release Date

2022 (2609)
2023 (2393)
2021 (2376)
2025 (2267)
2024 (1819)
2020 (1747)
2019 (1257)
2018 (1112)
2017 (953)
2016 (755)
2015 (712)
2014 (589)
2013 (415)
2012 (360)
2026 (328)
2011 (292)
2010 (272)
2009 (166)
2008 (133)
2007 (74)
2006 (42)
2005 (39)
2004 (28)
2003 (13)
2001 (8)
2000 (8)
2002 (6)
1999 (6)
1998 (5)
1997 (1)

Location

United States (203)
China (47)
Japan (40)
Spain (35)
Italy (31)
Germany (30)
France (29)
United Kingdom (26)
South Korea (23)
Belgium (23)
Canada (21)
Australia (15)
Denmark (11)
Poland (10)
Austria (10)
Netherlands (9)
Taiwan (8)
Israel (7)
Czechia (7)
Hungary (7)
Russia (5)
Brazil (5)
Georgia (3)
Hong Kong (3)
Singapore (3)
Sweden (3)
Puerto Rico (2)
Portugal (2)
Argentina (2)
Switzerland (2)

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Michigan Biomarkers for Refractory Depression (Bluebird) metabolomics pilot study

Not available

ORGANISM(S): Homo sapiens

ST000775 | MetabolomicsWorkbench

Ferritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights

RNA expression profiles in CD34+ and in stromal cells of patients with refractory anemia with ringed sideroblasts

Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcri...

ORGANISM(S): Homo sapiens

2010-06-22 | E-GEOD-18911 | biostudies-arrayexpress

Proteomics of EBV-infected lytic and refractory cells

Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cell...

ORGANISM(S): Homo sapiens (Human)

2016-04-27 | PXD001838 | Pride

Refractory Cancer (RC) Program

PRJNA663002 | ENA

Refractory Cancer (RC) Program

PRJNA663003 | ENA

Proteogenomic analysis of chemo-refractory high grade serous ovarian cancer

To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...

ORGANISM(S): Homo Sapiens

PXD040742 | panorama

Proteomics of EBV-infected lytic and refractory cells

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-07-22 | MSV000079993 | MassIVE

Proteomic analysis of radioiodine-refractory differentiated thyroid cancer

Radioiodine refractory differentiated thyroid cancer (RR-DTC) is the main factor affecting the overall survival rate of thyroid cancer clinically. In order to investigate its underlying molecular mechanism of pathogenesis with the hope to explore novel therapeutic targets for clinical treatment, we ...

ORGANISM(S): Homo Sapiens

2022-11-05 | PXD037968 |

Genomic Analysis of Relapsed/Refractory DLBCL

PRJNA1200817 | ENA

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