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TranscriptomicsIdentification of a CD271-associated signaling network in human malignant melanoma cells
Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the differentiation of melanoma-initiating ...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-52456 | biostudies-arrayexpress
TranscriptomicsDeciphering targets of CD271-dependent signaling processes
Genome-wide expression profiling of stably NGFR transfected melanoma cells was used to identify genes driven by expression of the nerve growth factor receptor CD271 (NGFR). Stable overexpression of NGFR (CD271): Generation of cell lines stably overexpressing CD271 (NGFR), melanoma cells were transfe...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78155 | biostudies-arrayexpress
MetabolomicsMulti-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms in, e.g. APOC3, ...
2015-12-07 | MTBLS174 | MetaboLights
TranscriptomicsClassifying distinct grades of human non-alcoholic fatty liver disease employing a systems biology approach
With an estimated prevalence of about 30% in western countries non-alcoholic fatty liver disease (NAFLD) is a major public health issue [PMID: 18956290]. NAFLD is associated with the metabolic syndrome of insulin resistance, obesity, glucose intolerance. Although many studies are pointing to an indu...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-GEOD-46300 | biostudies-arrayexpress
GenomicsDissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors
Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...
EGAS00001001752 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:08:19:631-106 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer metastasis sample
EGAD00001002084 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:21:37:629-120 - samples
Whole-exome sequencing on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample
EGAD00001002098 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:25:47:437-127 - samples
Whole-exome sequencing on AB 5500xl Genetic Analyzer of colorectal cancer metastasis sample
EGAD00001002105 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:10:37:045-110 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer primary tumor sample
EGAD00001002088 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:16:33:021-1359 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample (OT2_cohort)
EGAD00001003366 | EGA
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